FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064091851> ?p ?o ?g. }

• W2064091851 endingPage "134" @default.
• W2064091851 startingPage "129" @default.
• W2064091851 abstract "Vitiligo is an acquired epidermal pigment loss of the skin. Oxidative stress is one of the major theories in the pathophysiology of vitiligo. FOXO3A is the forkhead members of the class O (FOXO) transcription factors, and plays an important role in cell cycle regulation, apoptosis, oxidative stress, and DNA repair. The aim of our study was to investigate FOXO3A gene polymorphisms and FOXO3A protein levels, activities of superoxide dismutase (SOD) and catalase antioxidant enzymes in vitiligo patients and healthy controls. Moreover, the level of plasma advanced oxidation protein products (AOPP) in subjects was evaluated to understand the possible role of protein oxidation in disease etiology. Study groups included 82 vitiligo patients and 81 unrelated healthy controls. FOXO3A polymorphisms were determined using polymerase chain reaction–restriction fragment length polymorphism method. FOXO3A levels and catalase activity were measured by ELISA whereas AOPP levels and SOD activity was measured by spectrophotometric analysis. We found a significant relationship between rs4946936 polymorphism of FOXO3A gene and vitiligo/active vitiligo patients (p = 0.017; p = 0.019 respectively), but not for rs2253310 (p > 0.05). SOD activity and AOPP levels of vitiligo patient were increased compared with control group, whereas FOXO3A levels and catalase enzyme activity of vitiligo patient were decreased compared with control group (p < 0.05). Our study indicates that rs4946936 of FOXO3A gene may associate susceptibility of vitiligo, especially active vitiligo. Moreover, our results confirm that oxidative stress may play a role in the pathophysiology of vitiligo. Further studies with larger samples are required to elucidate the role of FOXO3A in vitiligo." @default.
• W2064091851 created "2016-06-24" @default.
• W2064091851 creator A5036814267 @default.
• W2064091851 creator A5036858212 @default.
• W2064091851 creator A5042799373 @default.
• W2064091851 creator A5050249346 @default.
• W2064091851 creator A5087559496 @default.
• W2064091851 date "2014-02-01" @default.
• W2064091851 modified "2023-09-26" @default.
• W2064091851 title "The association of FOXO3A gene polymorphisms with serum FOXO3A levels and oxidative stress markers in vitiligo patients" @default.
• W2064091851 cites W1513154658 @default.
• W2064091851 cites W1518164640 @default.
• W2064091851 cites W1823918878 @default.
• W2064091851 cites W1965684670 @default.
• W2064091851 cites W1971206408 @default.
• W2064091851 cites W1976074961 @default.
• W2064091851 cites W1978968368 @default.
• W2064091851 cites W1986097454 @default.
• W2064091851 cites W1988199837 @default.
• W2064091851 cites W1992444358 @default.
• W2064091851 cites W2002067384 @default.
• W2064091851 cites W2003680709 @default.
• W2064091851 cites W2017326328 @default.
• W2064091851 cites W2020877539 @default.
• W2064091851 cites W2023973783 @default.
• W2064091851 cites W2027452552 @default.
• W2064091851 cites W2028755866 @default.
• W2064091851 cites W2033106309 @default.
• W2064091851 cites W2041771374 @default.
• W2064091851 cites W2042641359 @default.
• W2064091851 cites W2044172489 @default.
• W2064091851 cites W2054277474 @default.
• W2064091851 cites W2054891396 @default.
• W2064091851 cites W2056247303 @default.
• W2064091851 cites W2061427976 @default.
• W2064091851 cites W2061431107 @default.
• W2064091851 cites W2067799923 @default.
• W2064091851 cites W2076152557 @default.
• W2064091851 cites W2083516240 @default.
• W2064091851 cites W2084698816 @default.
• W2064091851 cites W2088123831 @default.
• W2064091851 cites W2097450722 @default.
• W2064091851 cites W2099364141 @default.
• W2064091851 cites W2112954051 @default.
• W2064091851 cites W2116787167 @default.
• W2064091851 cites W2124898423 @default.
• W2064091851 cites W2129381792 @default.
• W2064091851 cites W2132399579 @default.
• W2064091851 cites W2135017906 @default.
• W2064091851 cites W2136250296 @default.
• W2064091851 cites W2137035181 @default.
• W2064091851 cites W2150449576 @default.
• W2064091851 cites W2159305277 @default.
• W2064091851 cites W2162857699 @default.
• W2064091851 cites W2163453199 @default.
• W2064091851 cites W4242718573 @default.
• W2064091851 doi "https://doi.org/10.1016/j.gene.2013.11.055" @default.
• W2064091851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24365591" @default.
• W2064091851 hasPublicationYear "2014" @default.
• W2064091851 type Work @default.
• W2064091851 sameAs 2064091851 @default.
• W2064091851 citedByCount "30" @default.
• W2064091851 countsByYear W20640918512014 @default.
• W2064091851 countsByYear W20640918512015 @default.
• W2064091851 countsByYear W20640918512016 @default.
• W2064091851 countsByYear W20640918512017 @default.
• W2064091851 countsByYear W20640918512018 @default.
• W2064091851 countsByYear W20640918512019 @default.
• W2064091851 countsByYear W20640918512020 @default.
• W2064091851 countsByYear W20640918512021 @default.
• W2064091851 countsByYear W20640918512022 @default.
• W2064091851 countsByYear W20640918512023 @default.
• W2064091851 crossrefType "journal-article" @default.
• W2064091851 hasAuthorship W2064091851A5036814267 @default.
• W2064091851 hasAuthorship W2064091851A5036858212 @default.
• W2064091851 hasAuthorship W2064091851A5042799373 @default.
• W2064091851 hasAuthorship W2064091851A5050249346 @default.
• W2064091851 hasAuthorship W2064091851A5087559496 @default.
• W2064091851 hasConcept C126322002 @default.
• W2064091851 hasConcept C134018914 @default.
• W2064091851 hasConcept C203014093 @default.
• W2064091851 hasConcept C2775838275 @default.
• W2064091851 hasConcept C2776151105 @default.
• W2064091851 hasConcept C2778979269 @default.
• W2064091851 hasConcept C2779980618 @default.
• W2064091851 hasConcept C71924100 @default.
• W2064091851 hasConcept C86803240 @default.
• W2064091851 hasConceptScore W2064091851C126322002 @default.
• W2064091851 hasConceptScore W2064091851C134018914 @default.
• W2064091851 hasConceptScore W2064091851C203014093 @default.
• W2064091851 hasConceptScore W2064091851C2775838275 @default.
• W2064091851 hasConceptScore W2064091851C2776151105 @default.
• W2064091851 hasConceptScore W2064091851C2778979269 @default.
• W2064091851 hasConceptScore W2064091851C2779980618 @default.
• W2064091851 hasConceptScore W2064091851C71924100 @default.
• W2064091851 hasConceptScore W2064091851C86803240 @default.
• W2064091851 hasIssue "1" @default.
• W2064091851 hasLocation W20640918511 @default.

• next