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- W2064107967 abstract "RATIONALE: The recent NAEPP EPR-3 asthma guidelines emphasize the measurement of impairment from asthma and suggest the regular use of two validated questionnaires, the ACT (Asthma Control Test) and the ATAQ (Asthma Therapy Assessment Questionnaire) to determine the degree of control of asthma. As we have previously shown levels of the complement split product (CSP) plasma C5a desArg correlate with asthma quality of life scores (AQLQ, Juniper)(Charlot, 2005), we determined whether C5a desArg or C3a desArg and their peripheral blood receptor levels (CSPr) correlate with asthma control in adult asthmatics seen in an outpatient setting. METHODS: During a single study visit plasma and peripheral blood cellular receptor levels of C5a desArg and C3a desArg, and total serum IgE (ELISA, flow cytometry, and fluorescence enzyme immunoassay) were obtained from adult patients with allergic asthma (n = 14), allergic rhinoconjunctivitis (n = 4), or controls (n = 4). After completing the ACT and ATAQ questionnaires, subjects underwent measurement of exhaled nitric oxide (Niox Mino) and spirometry. RESULTS: Increased levels of plasma C3a desArg and its lymphocyte receptor (LC3aR) correlate with decreased asthma control as measured by the ATAQ (p = 0.04 for both). The correlation of monocyte C3aR levels with ATAQ, C5a-desArg levels with ACT score, and lymphocyte C5aR level CD88) with ATAQ all approached significance (p = 0.08, 0.06, and 0.06, respectively). CONCLUSIONS: Taken together, our findings suggest that both CSP and CSPr levels correlate with both asthma quality of life and asthma control and there is a degree of increased systemic inflammation involving complement in patients with poorly controlled asthma." @default.
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- W2064107967 date "2009-02-01" @default.
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- W2064107967 title "Levels of Plasma Complement Split Products C3a desArg and C5a desArg and their Peripheral Blood Receptors are Elevated in Outpatient Adult Asthmatics with Decreased Asthma Control as Determined by the ACT and ATAQ Questionnaires" @default.
- W2064107967 doi "https://doi.org/10.1016/j.jaci.2008.12.294" @default.
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