Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064114479> ?p ?o ?g. }
- W2064114479 endingPage "675" @default.
- W2064114479 startingPage "667" @default.
- W2064114479 abstract "Combination sulfonylurea-insulin therapy for patients with diabetes mellitus has been evaluated by numerous investigators with various experimental designs. Much of the data are conflicting, and clear conclusions do not seem justified. Insulin-sulfonylurea therapy is probably not clinically useful in most patients with insulin-dependent diabetes mellitus. Most non-insulin-dependent diabetic (NIDDM) patients are also unlikely to have meaningful improvement in glycemic regulation on insulin-sulfonylurea therapy. A subset of NIDDM patients who are mildly to moderately obese, have adequate endogenous insulin secretory reserve, and are in poor glycemic regulation (fasting plasma glucose greater than 11 mM and/or HbA1 greater than 10%), despite twice-daily insulin administration of greater than 70 U/day, may show significant improvement of glycemic regulation and/or decreases in insulin daily dose on insulin-sulfonylurea therapy. The mechanisms by which insulin-sulfonylurea therapy improves glycemic regulation and decreases insulin requirements involve an increase in endogenous insulin secretion and possibly some extrapancreatic actions of the sulfonylureas on muscle and liver." @default.
- W2064114479 created "2016-06-24" @default.
- W2064114479 creator A5001574834 @default.
- W2064114479 creator A5013804150 @default.
- W2064114479 date "1990-06-01" @default.
- W2064114479 modified "2023-09-23" @default.
- W2064114479 title "Combination Insulin-Sulfonylurea Therapy" @default.
- W2064114479 cites W1723304096 @default.
- W2064114479 cites W1971735908 @default.
- W2064114479 cites W1991255033 @default.
- W2064114479 cites W2006071812 @default.
- W2064114479 cites W2009460889 @default.
- W2064114479 cites W2014753183 @default.
- W2064114479 cites W2022887456 @default.
- W2064114479 cites W2026681221 @default.
- W2064114479 cites W2027511937 @default.
- W2064114479 cites W2029689003 @default.
- W2064114479 cites W2031639187 @default.
- W2064114479 cites W2033895007 @default.
- W2064114479 cites W2043269645 @default.
- W2064114479 cites W2045110608 @default.
- W2064114479 cites W2045580983 @default.
- W2064114479 cites W2045712333 @default.
- W2064114479 cites W2050219770 @default.
- W2064114479 cites W2050676408 @default.
- W2064114479 cites W2055645626 @default.
- W2064114479 cites W2057847857 @default.
- W2064114479 cites W2061452623 @default.
- W2064114479 cites W2065593938 @default.
- W2064114479 cites W2070710762 @default.
- W2064114479 cites W2071223925 @default.
- W2064114479 cites W2072515825 @default.
- W2064114479 cites W2073141187 @default.
- W2064114479 cites W2087080454 @default.
- W2064114479 cites W2088065710 @default.
- W2064114479 cites W2089615575 @default.
- W2064114479 cites W2093332629 @default.
- W2064114479 cites W2101084631 @default.
- W2064114479 cites W2102050309 @default.
- W2064114479 cites W2119571022 @default.
- W2064114479 cites W2138820053 @default.
- W2064114479 cites W2160382173 @default.
- W2064114479 cites W2161986582 @default.
- W2064114479 cites W2317353168 @default.
- W2064114479 cites W2321615924 @default.
- W2064114479 cites W2410080958 @default.
- W2064114479 cites W2413918878 @default.
- W2064114479 cites W2414265203 @default.
- W2064114479 cites W2463064414 @default.
- W2064114479 cites W2467906684 @default.
- W2064114479 cites W2471283800 @default.
- W2064114479 cites W2471553520 @default.
- W2064114479 cites W2888818251 @default.
- W2064114479 cites W2401806654 @default.
- W2064114479 doi "https://doi.org/10.2337/diacare.13.6.667" @default.
- W2064114479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2192850" @default.
- W2064114479 hasPublicationYear "1990" @default.
- W2064114479 type Work @default.
- W2064114479 sameAs 2064114479 @default.
- W2064114479 citedByCount "51" @default.
- W2064114479 countsByYear W20641144792012 @default.
- W2064114479 countsByYear W20641144792014 @default.
- W2064114479 countsByYear W20641144792015 @default.
- W2064114479 countsByYear W20641144792018 @default.
- W2064114479 countsByYear W20641144792019 @default.
- W2064114479 crossrefType "journal-article" @default.
- W2064114479 hasAuthorship W2064114479A5001574834 @default.
- W2064114479 hasAuthorship W2064114479A5013804150 @default.
- W2064114479 hasConcept C126322002 @default.
- W2064114479 hasConcept C134018914 @default.
- W2064114479 hasConcept C2778854520 @default.
- W2064114479 hasConcept C2779306644 @default.
- W2064114479 hasConcept C2780473172 @default.
- W2064114479 hasConcept C555293320 @default.
- W2064114479 hasConcept C71924100 @default.
- W2064114479 hasConceptScore W2064114479C126322002 @default.
- W2064114479 hasConceptScore W2064114479C134018914 @default.
- W2064114479 hasConceptScore W2064114479C2778854520 @default.
- W2064114479 hasConceptScore W2064114479C2779306644 @default.
- W2064114479 hasConceptScore W2064114479C2780473172 @default.
- W2064114479 hasConceptScore W2064114479C555293320 @default.
- W2064114479 hasConceptScore W2064114479C71924100 @default.
- W2064114479 hasIssue "6" @default.
- W2064114479 hasLocation W20641144791 @default.
- W2064114479 hasLocation W20641144792 @default.
- W2064114479 hasOpenAccess W2064114479 @default.
- W2064114479 hasPrimaryLocation W20641144791 @default.
- W2064114479 hasRelatedWork W1983641721 @default.
- W2064114479 hasRelatedWork W1995945960 @default.
- W2064114479 hasRelatedWork W2026226896 @default.
- W2064114479 hasRelatedWork W2029170600 @default.
- W2064114479 hasRelatedWork W2041678535 @default.
- W2064114479 hasRelatedWork W2066345847 @default.
- W2064114479 hasRelatedWork W2089387278 @default.
- W2064114479 hasRelatedWork W2095179743 @default.
- W2064114479 hasRelatedWork W2130904138 @default.
- W2064114479 hasRelatedWork W4230655895 @default.
- W2064114479 hasVolume "13" @default.