FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064121493> ?p ?o ?g. }

• W2064121493 endingPage "13400" @default.
• W2064121493 startingPage "13393" @default.
• W2064121493 abstract "Disinfection of wastewater treatment plant effluent may be an important barrier for limiting the spread of antibiotic-resistant bacteria (ARBs) and antibiotic resistance genes (ARGs). While ideally disinfection should destroy ARGs, to prevent horizontal gene transfer to downstream bacteria, little is known about the effect of conventional water disinfection technologies on ARGs. This study examined the potential of UV disinfection to damage four ARGs, mec(A), van(A), tet(A), and amp(C), both in extracellular form and present within a host ARBs: methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE), Escherichia coli SMS-3-5, and Pseudomonas aeruginosa 01, respectively. An extended amplicon-length quantitative polymerase chain reaction assay was developed to enhance capture of ARG damage events and also to normalize to an equivalent length of target DNA (∼1000 bp) for comparison. It was found that the two Gram-positive ARBs (MRSA and VRE) were more resistant to UV disinfection than the two Gram-negative ARBs (E. coli and P. aeruginosa). The two Gram-positive organisms also possessed smaller total genome sizes, which could also have reduced their susceptibility to UV because of fewer potential pyrimidine dimer targets. An effect of cell type on damage to ARGs was only observed in VRE and P. aeruginosa, the latter potentially because of extracellular polymeric substances. In general, damage of ARGs required much greater UV doses (200–400 mJ/cm2 for 3- to 4-log reduction) than ARB inactivation (10–20 mJ/cm2 for 4- to 5-log reduction). The proportion of amplifiable ARGs following UV treatment exhibited a strong negative correlation with the number of adjacent thymines (Pearson r < −0.9; p < 0.0001). ARBs surviving UV treatment were negatively correlated with total genome size (Pearson r < −0.9; p < 0.0001) and adjacent cytosines (Pearson r < −0.88; p < 0.0001) but positively correlated with adjacent thymines (Pearson r > 0.85; p < 0.0001). This suggests that formation of thymine dimers is not the sole mechanism of ARB inactivation. Overall, the results indicate that UV is limited in its potential to damage ARGs and other disinfection technologies should be explored." @default.
• W2064121493 created "2016-06-24" @default.
• W2064121493 creator A5014657905 @default.
• W2064121493 creator A5046181665 @default.
• W2064121493 date "2012-11-29" @default.
• W2064121493 modified "2023-10-11" @default.
• W2064121493 title "Ultraviolet Disinfection of Antibiotic Resistant Bacteria and Their Antibiotic Resistance Genes in Water and Wastewater" @default.
• W2064121493 cites W1491637723 @default.
• W2064121493 cites W1591872662 @default.
• W2064121493 cites W1966393989 @default.
• W2064121493 cites W1978913977 @default.
• W2064121493 cites W1993147084 @default.
• W2064121493 cites W1994804977 @default.
• W2064121493 cites W1995274825 @default.
• W2064121493 cites W2002452303 @default.
• W2064121493 cites W2013345078 @default.
• W2064121493 cites W2024730159 @default.
• W2064121493 cites W2026038510 @default.
• W2064121493 cites W2034242326 @default.
• W2064121493 cites W2035877597 @default.
• W2064121493 cites W2037278032 @default.
• W2064121493 cites W2046501778 @default.
• W2064121493 cites W2049115958 @default.
• W2064121493 cites W2050471630 @default.
• W2064121493 cites W205410959 @default.
• W2064121493 cites W2058952776 @default.
• W2064121493 cites W2062865935 @default.
• W2064121493 cites W2065624425 @default.
• W2064121493 cites W2076688480 @default.
• W2064121493 cites W2076973798 @default.
• W2064121493 cites W2077668745 @default.
• W2064121493 cites W2083018796 @default.
• W2064121493 cites W2083397410 @default.
• W2064121493 cites W2093993489 @default.
• W2064121493 cites W2099303284 @default.
• W2064121493 cites W2103847950 @default.
• W2064121493 cites W2107925657 @default.
• W2064121493 cites W2108638835 @default.
• W2064121493 cites W2115127793 @default.
• W2064121493 cites W2117811009 @default.
• W2064121493 cites W2117886977 @default.
• W2064121493 cites W2120316710 @default.
• W2064121493 cites W2125420295 @default.
• W2064121493 cites W2125731426 @default.
• W2064121493 cites W2143194729 @default.
• W2064121493 cites W2145013481 @default.
• W2064121493 cites W2149353640 @default.
• W2064121493 cites W2149425658 @default.
• W2064121493 cites W2166425259 @default.
• W2064121493 cites W2170377310 @default.
• W2064121493 cites W4210969014 @default.
• W2064121493 doi "https://doi.org/10.1021/es303652q" @default.
• W2064121493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23153396" @default.
• W2064121493 hasPublicationYear "2012" @default.
• W2064121493 type Work @default.
• W2064121493 sameAs 2064121493 @default.
• W2064121493 citedByCount "386" @default.
• W2064121493 countsByYear W20641214932013 @default.
• W2064121493 countsByYear W20641214932014 @default.
• W2064121493 countsByYear W20641214932015 @default.
• W2064121493 countsByYear W20641214932016 @default.
• W2064121493 countsByYear W20641214932017 @default.
• W2064121493 countsByYear W20641214932018 @default.
• W2064121493 countsByYear W20641214932019 @default.
• W2064121493 countsByYear W20641214932020 @default.
• W2064121493 countsByYear W20641214932021 @default.
• W2064121493 countsByYear W20641214932022 @default.
• W2064121493 countsByYear W20641214932023 @default.
• W2064121493 crossrefType "journal-article" @default.
• W2064121493 hasAuthorship W2064121493A5014657905 @default.
• W2064121493 hasAuthorship W2064121493A5046181665 @default.
• W2064121493 hasConcept C104317684 @default.
• W2064121493 hasConcept C185592680 @default.
• W2064121493 hasConcept C2777637488 @default.
• W2064121493 hasConcept C2777677444 @default.
• W2064121493 hasConcept C2779489039 @default.
• W2064121493 hasConcept C2780585763 @default.
• W2064121493 hasConcept C2780923616 @default.
• W2064121493 hasConcept C501593827 @default.
• W2064121493 hasConcept C523546767 @default.
• W2064121493 hasConcept C54355233 @default.
• W2064121493 hasConcept C547475151 @default.
• W2064121493 hasConcept C55493867 @default.
• W2064121493 hasConcept C86803240 @default.
• W2064121493 hasConcept C89423630 @default.
• W2064121493 hasConcept C94665300 @default.
• W2064121493 hasConceptScore W2064121493C104317684 @default.
• W2064121493 hasConceptScore W2064121493C185592680 @default.
• W2064121493 hasConceptScore W2064121493C2777637488 @default.
• W2064121493 hasConceptScore W2064121493C2777677444 @default.
• W2064121493 hasConceptScore W2064121493C2779489039 @default.
• W2064121493 hasConceptScore W2064121493C2780585763 @default.
• W2064121493 hasConceptScore W2064121493C2780923616 @default.
• W2064121493 hasConceptScore W2064121493C501593827 @default.
• W2064121493 hasConceptScore W2064121493C523546767 @default.
• W2064121493 hasConceptScore W2064121493C54355233 @default.
• W2064121493 hasConceptScore W2064121493C547475151 @default.
• W2064121493 hasConceptScore W2064121493C55493867 @default.

• next