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• W2064125896 abstract "Staphylococcus aureus (SA) is a major community-acquired pathogen. The emergence of drug-resistant strains like, methicillin-resistant SA (MRSA), poses stiff challenges to therapeutic intervention. Passive immune-therapy with specific antibodies is being actively examined to treat fulminant infections with limited success. In this study, we demonstrate that P4, a 28-amino acid peptide, derived from pneumococcal surface adhesin A along with pathogen-specific antibody (IVIG; P4 therapy) is successful in enhancing the opsonophagocytic killing (OPK) of S. aureus in vitro . We questioned if it is possible to expand P4 therapy to treat staphylococcal infections in vivo . P4 therapy in combination with IVIG rescued 7/10 morbidly ill S. aureus -infected mice while only 2/10 survived in the control group." @default.
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• W2064125896 date "2011-01-01" @default.
• W2064125896 modified "2023-09-25" @default.
• W2064125896 title "A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from FatalStaphylococcus aureusSepticemia" @default.
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• W2064125896 doi "https://doi.org/10.1155/2011/725483" @default.
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