Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064133670> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2064133670 endingPage "143" @default.
- W2064133670 startingPage "139" @default.
- W2064133670 abstract "The effect of phenobarbital administration on theophylline clearance was studied in 24 premature neonates. Aminophylline was administered according to a standard protocol of 6 mg/kg loading dose followed by a maintenance dose of 2.5-5 mg/kg/12 h. Of the 24 neonates studied, 12 received a mean phenobarbital dose of 26.34 mg/kg/d (ranging from 2 mg every 24 h to 25 mg every 12 h) and the mean phenobarbital concentration was 56.12 micrograms/ml (range 22-112 micrograms/ml). The remaining 12 patients did not require phenobarbital therapy but did receive aminophylline alone. The two groups were closely matched for gestational age, 5-min Apgar scores, and sex (p greater than 0.2). Steady-state theophylline clearance was determined at least once a week for four or more separate weeks. The study lasted a minimum of 8 wk and if more than one theophylline clearance was determined in any given week, the mean of these clearances was used. Both groups demonstrated an increase in mean theophylline clearance over time (from 15.75 and 16.67 ml/h/kg to 30.33 and 35.42 ml/h/kg for the aminophylline and aminophylline plus phenobarbital groups, respectively). The mean slope, an indicator of the average change in theophylline clearance, was 2.19 for the aminophylline group and 3.27 for the aminophylline plus phenobarbital group (p greater than 0.2), indicating that the theophylline clearance for neonates receiving phenobarbital was not significantly different from that for neonates receiving aminophylline alone. Based on this information, aminophylline does not need to be adjusted solely based on concomitant phenobarbital administration; however, theophylline concentrations should be monitored since theophylline clearance can change rapidly and unpredictably in neonates." @default.
- W2064133670 created "2016-06-24" @default.
- W2064133670 creator A5034766496 @default.
- W2064133670 creator A5051067785 @default.
- W2064133670 creator A5070409215 @default.
- W2064133670 creator A5087396740 @default.
- W2064133670 creator A5088561067 @default.
- W2064133670 date "1990-03-01" @default.
- W2064133670 modified "2023-09-26" @default.
- W2064133670 title "Effect of Phenobarbital Administration on Theophylline Clearance in Premature Neonates" @default.
- W2064133670 doi "https://doi.org/10.1097/00007691-199003000-00005" @default.
- W2064133670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2180136" @default.
- W2064133670 hasPublicationYear "1990" @default.
- W2064133670 type Work @default.
- W2064133670 sameAs 2064133670 @default.
- W2064133670 citedByCount "9" @default.
- W2064133670 countsByYear W20641336702013 @default.
- W2064133670 countsByYear W20641336702020 @default.
- W2064133670 countsByYear W20641336702022 @default.
- W2064133670 crossrefType "journal-article" @default.
- W2064133670 hasAuthorship W2064133670A5034766496 @default.
- W2064133670 hasAuthorship W2064133670A5051067785 @default.
- W2064133670 hasAuthorship W2064133670A5070409215 @default.
- W2064133670 hasAuthorship W2064133670A5087396740 @default.
- W2064133670 hasAuthorship W2064133670A5088561067 @default.
- W2064133670 hasConcept C112705442 @default.
- W2064133670 hasConcept C126322002 @default.
- W2064133670 hasConcept C2776202631 @default.
- W2064133670 hasConcept C2778095195 @default.
- W2064133670 hasConcept C2778376644 @default.
- W2064133670 hasConcept C2778793413 @default.
- W2064133670 hasConcept C2779234561 @default.
- W2064133670 hasConcept C27924281 @default.
- W2064133670 hasConcept C35294091 @default.
- W2064133670 hasConcept C42219234 @default.
- W2064133670 hasConcept C54355233 @default.
- W2064133670 hasConcept C71924100 @default.
- W2064133670 hasConcept C86803240 @default.
- W2064133670 hasConceptScore W2064133670C112705442 @default.
- W2064133670 hasConceptScore W2064133670C126322002 @default.
- W2064133670 hasConceptScore W2064133670C2776202631 @default.
- W2064133670 hasConceptScore W2064133670C2778095195 @default.
- W2064133670 hasConceptScore W2064133670C2778376644 @default.
- W2064133670 hasConceptScore W2064133670C2778793413 @default.
- W2064133670 hasConceptScore W2064133670C2779234561 @default.
- W2064133670 hasConceptScore W2064133670C27924281 @default.
- W2064133670 hasConceptScore W2064133670C35294091 @default.
- W2064133670 hasConceptScore W2064133670C42219234 @default.
- W2064133670 hasConceptScore W2064133670C54355233 @default.
- W2064133670 hasConceptScore W2064133670C71924100 @default.
- W2064133670 hasConceptScore W2064133670C86803240 @default.
- W2064133670 hasIssue "2" @default.
- W2064133670 hasLocation W20641336701 @default.
- W2064133670 hasLocation W20641336702 @default.
- W2064133670 hasOpenAccess W2064133670 @default.
- W2064133670 hasPrimaryLocation W20641336701 @default.
- W2064133670 hasRelatedWork W1988547824 @default.
- W2064133670 hasRelatedWork W2030294399 @default.
- W2064133670 hasRelatedWork W2064133670 @default.
- W2064133670 hasRelatedWork W2079965136 @default.
- W2064133670 hasRelatedWork W2147832660 @default.
- W2064133670 hasRelatedWork W2166786099 @default.
- W2064133670 hasRelatedWork W2314701060 @default.
- W2064133670 hasRelatedWork W2407130331 @default.
- W2064133670 hasRelatedWork W2415048045 @default.
- W2064133670 hasRelatedWork W2473983298 @default.
- W2064133670 hasVolume "12" @default.
- W2064133670 isParatext "false" @default.
- W2064133670 isRetracted "false" @default.
- W2064133670 magId "2064133670" @default.
- W2064133670 workType "article" @default.