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- W2064144421 abstract "Guanine- (G-) rich nucleic acid sequences can form four-stranded structures called G-quadruplexes. It is widely held that the formation of a G-quadruplex in RNA is more feasible than in DNA because of the lack of a complementary strand in mRNA. Here, we analyzed sequences of 5′-untranslated regions of protooncogenes and surprisingly found that these regions showed an enrichment of not only guanine (G) but also cytosine (C) nucleotides. Since neighboring cytosine- (C-) rich regions can affect the formation and stability of a G-quadruplex structure, we further investigated the properties of DNA and RNA structures of G-rich and GC-rich regions. We selected typical GC-rich RNA sequences from protooncogenes and corresponding DNA sequences and investigated their structures. It was found that the GC-rich RNA sequences formed stable A-form duplexes as their major structure independent of the surrounding conditions, including the presence of different cations (Na+, K+, or Li+) or molecular crowding with 40 wt % poly(ethylene glycol) with an average molecular mass of 200 Da although there are a few exceptions in which only a combination of K+ and molecular crowding induced a G-quadruplex structure of an extremely G-rich RNA sequence. In contrast, structural polymorphisms involving duplexes, G-quadruplexes, and i-motifs were observed for GC-rich DNA sequences depending on the surrounding factors. These results demonstrate the considerable structural and functional differences in GC-rich sequences of the genome (DNA) and transcriptosome (mRNA) with respect to the nucleic acid backbone. Moreover, it was suggested that structural study for a G-rich RNA sequence should be carried out under cell-mimicking condition where K+ and crowding cosolutes exist." @default.
- W2064144421 created "2016-06-24" @default.
- W2064144421 creator A5041513545 @default.
- W2064144421 creator A5058387972 @default.
- W2064144421 creator A5090515638 @default.
- W2064144421 date "2010-07-30" @default.
- W2064144421 modified "2023-09-26" @default.
- W2064144421 title "Sole and Stable RNA Duplexes of G-Rich Sequences Located in the 5′-Untranslated Region of Protooncogenes" @default.
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- W2064144421 doi "https://doi.org/10.1021/bi101093a" @default.
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- W2064144421 hasPublicationYear "2010" @default.
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