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- W2064158216 abstract "We have examined the effect of clodronate on skeletal morbidity in myeloma in a double-blind placebo controlled trial. 615 patients were randomised at diagnosis to receive either clodronate 1600 mg daily by mouth (n = 304) or an identical placebo (n = 305) in addition to chemotherapy. There was no difference in the initial symptomatic response between the dodronate and placebo-treated patients. In contrast, at relapse, the proportion of patients with poor performance status was significantly lower in those receiving clodronate (RR 0.52, 95CI 0.32–0.83). Fewer patients experienced a marked increase in back pain (RR 0.48, 95CI 0.13–0.89) and a similar trend was observed for rib pain (RR 0.34, 95CI 0.10–1.21). Fewer patients experienced new vertebral fractures after the first year in the clodronate wing (RR 0.72, 95CI 0.51–1.01) with fracture rates of 33 and 54 new fractures/100 patient years respectively (P We conclude that long-term oral clodronate modifies the progression of skeletal disease and provides a useful adjunct to clinical management." @default.
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- W2064158216 date "1995-11-01" @default.
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- W2064158216 title "775 Effect of clodronate on progression of skeletal disease in multiple myelomatosis" @default.
- W2064158216 doi "https://doi.org/10.1016/0959-8049(95)96024-8" @default.
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