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- W2064188840 abstract "A number of phosphoramidite monomers have been prepared and used in the synthesis of antisense phosphorothioate oligonucleotides bearing 5'-polyalkyl and cholesterol moieties. Similar groups have also been attached to the 3'-end of oligonucleotides by means of functionalised CPG. Melting temperatures of duplexes formed between phosphorothioate oligonucleotides with lipophilic end-groups and complementary DNA strands were found to be identical to those formed by the equivalent unmodified phosphorothioates." @default.
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- W2064188840 title "Synthesis and physical properties ofanti-HIV antisense oligonucleotides bearing terminal lipophilic groups" @default.
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- W2064188840 doi "https://doi.org/10.1093/nar/20.13.3411" @default.
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