FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064202227> ?p ?o ?g. }

• W2064202227 endingPage "60" @default.
• W2064202227 startingPage "51" @default.
• W2064202227 abstract "The Drosophila homeotic gene proboscipedia (pb) specifies labial identity and directs formation of the adult distiproboscis from the labial imaginal discs. pb null alleles result in the homeotic transformation of the distiproboscis into prothoracic (T1) legs [Kaufman (1978) Genetics 90, 579–596; Pultz et al. (1988) Genes Dev. 2, 901–920]. Homology with other transcription factors, localization to the nucleus, and restricted embryonic and imaginal expression implicate the pb protein (PB) as a transcription factor. In order to examine the possible roles that PB may play in the specification of adult mouthparts, we have expressed PB in cells of wing, leg and eye-antennal imaginal discs and assayed for effects on the development of adult structures. We report here that the ectopic expression of PB in the imaginal discs under the control of the inducible GAL4 system [Brand and Perrimon (1993) Development 118, 401–415] alters the developmental program of adult legs into maxillary or labial palps. These homeotic transformations have an equal effect on all three sets of legs, indicating an activity that is not solely dependent upon the unique combinations of other homeotic genes present in each of the leg discs. Segment polarity genes required for establishing the AP compartment boundary were found to be undisturbed by ectopic PB. Furthermore, normal patterns of apoptosis are observed in animals expressing ectopic PB, indicating that PB does not alter or affect cell death. These results suggest that molecular events occurring downstream of the establishment of the compartment boundary are affected by ectopic PB expression in imaginal discs and point to a general role in ‘palp’ formation in addition to the specification of labial identity." @default.
• W2064202227 created "2016-06-24" @default.
• W2064202227 creator A5037744823 @default.
• W2064202227 creator A5044343242 @default.
• W2064202227 date "1997-02-01" @default.
• W2064202227 modified "2023-10-05" @default.
• W2064202227 title "Homeotic transformation of legs to mouthparts by proboscipedia expression in Drosophila imaginal discs" @default.
• W2064202227 cites W1850470395 @default.
• W2064202227 cites W1854018284 @default.
• W2064202227 cites W1861676737 @default.
• W2064202227 cites W1863636479 @default.
• W2064202227 cites W1906238116 @default.
• W2064202227 cites W1909297873 @default.
• W2064202227 cites W192672273 @default.
• W2064202227 cites W1941884118 @default.
• W2064202227 cites W1965117722 @default.
• W2064202227 cites W1987718027 @default.
• W2064202227 cites W1989259872 @default.
• W2064202227 cites W1990478485 @default.
• W2064202227 cites W1991484745 @default.
• W2064202227 cites W2000646745 @default.
• W2064202227 cites W2000871658 @default.
• W2064202227 cites W2006788765 @default.
• W2064202227 cites W2008004759 @default.
• W2064202227 cites W2010542092 @default.
• W2064202227 cites W2049425193 @default.
• W2064202227 cites W2049780277 @default.
• W2064202227 cites W2062682308 @default.
• W2064202227 cites W2063475293 @default.
• W2064202227 cites W2067507164 @default.
• W2064202227 cites W2080444658 @default.
• W2064202227 cites W2090481679 @default.
• W2064202227 cites W2091739086 @default.
• W2064202227 cites W2110643873 @default.
• W2064202227 cites W2111202552 @default.
• W2064202227 cites W2117065097 @default.
• W2064202227 cites W2120176717 @default.
• W2064202227 cites W2135391373 @default.
• W2064202227 cites W2183135260 @default.
• W2064202227 cites W2189282260 @default.
• W2064202227 cites W2219575153 @default.
• W2064202227 cites W2285987853 @default.
• W2064202227 cites W2422481370 @default.
• W2064202227 cites W321588607 @default.
• W2064202227 cites W64223723 @default.
• W2064202227 cites W7076690 @default.
• W2064202227 doi "https://doi.org/10.1016/s0925-4773(96)00649-1" @default.
• W2064202227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9106166" @default.
• W2064202227 hasPublicationYear "1997" @default.
• W2064202227 type Work @default.
• W2064202227 sameAs 2064202227 @default.
• W2064202227 citedByCount "41" @default.
• W2064202227 countsByYear W20642022272013 @default.
• W2064202227 countsByYear W20642022272015 @default.
• W2064202227 countsByYear W20642022272016 @default.
• W2064202227 countsByYear W20642022272018 @default.
• W2064202227 countsByYear W20642022272019 @default.
• W2064202227 countsByYear W20642022272021 @default.
• W2064202227 countsByYear W20642022272023 @default.
• W2064202227 crossrefType "journal-article" @default.
• W2064202227 hasAuthorship W2064202227A5037744823 @default.
• W2064202227 hasAuthorship W2064202227A5044343242 @default.
• W2064202227 hasBestOaLocation W20642022271 @default.
• W2064202227 hasConcept C104317684 @default.
• W2064202227 hasConcept C105702510 @default.
• W2064202227 hasConcept C193842886 @default.
• W2064202227 hasConcept C2780104201 @default.
• W2064202227 hasConcept C46751350 @default.
• W2064202227 hasConcept C54355233 @default.
• W2064202227 hasConcept C86339819 @default.
• W2064202227 hasConcept C86803240 @default.
• W2064202227 hasConcept C91986751 @default.
• W2064202227 hasConcept C95444343 @default.
• W2064202227 hasConcept C97037327 @default.
• W2064202227 hasConceptScore W2064202227C104317684 @default.
• W2064202227 hasConceptScore W2064202227C105702510 @default.
• W2064202227 hasConceptScore W2064202227C193842886 @default.
• W2064202227 hasConceptScore W2064202227C2780104201 @default.
• W2064202227 hasConceptScore W2064202227C46751350 @default.
• W2064202227 hasConceptScore W2064202227C54355233 @default.
• W2064202227 hasConceptScore W2064202227C86339819 @default.
• W2064202227 hasConceptScore W2064202227C86803240 @default.
• W2064202227 hasConceptScore W2064202227C91986751 @default.
• W2064202227 hasConceptScore W2064202227C95444343 @default.
• W2064202227 hasConceptScore W2064202227C97037327 @default.
• W2064202227 hasFunder F4320306082 @default.
• W2064202227 hasFunder F4320332161 @default.
• W2064202227 hasIssue "1" @default.
• W2064202227 hasLocation W20642022271 @default.
• W2064202227 hasLocation W20642022272 @default.
• W2064202227 hasOpenAccess W2064202227 @default.
• W2064202227 hasPrimaryLocation W20642022271 @default.
• W2064202227 hasRelatedWork W1191263723 @default.
• W2064202227 hasRelatedWork W1578932375 @default.
• W2064202227 hasRelatedWork W1783335103 @default.
• W2064202227 hasRelatedWork W1966244591 @default.
• W2064202227 hasRelatedWork W1983543927 @default.
• W2064202227 hasRelatedWork W2042570416 @default.

• next