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- W2064204240 abstract "Human, mouse and rats have 2 different cytochrome P-450 11β-hydroxylases in the adrenal cortex. The classical rat 11β-hydroxylase or CYP11B1 enzyme hydroxylates deoxycorticosterone to corticosterone and 18-hydroxydeoxycorticosterone and is located throughout the adrenal. The second aldosterone synthase or CYP11B2 enzyme is located in the zona glomerulosa and converts deoxycorticosterone to corticosterone, 18-hydroxycorticosterone and aldosterone. In rat the coding nucleotide sequence and the deduced amino acid sequences of the CYP11B1 and CYP11B2 genes are homologous by 88% and 83%,respectively. We have constructed two different hybrid cDNAs by exchanging two fragments of the rat CYP11B1 and CYP11B2 at the junction of the 5/6 exon and expressed them in COS 7 cells. The hybrid CYPH11B1 construct containing the first 5 exons of the CYP11B1 when expressed, retains 11β-hydroxylase activity, but cannot process corticosterone to 18-hydroxycorticosterone or aldosterone. The hybrid CYPH11B2 construct containing the first 5 exons of the CYP11B2 enzyme when expressed is inactive." @default.
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- W2064204240 date "1994-02-01" @default.
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- W2064204240 title "The Hybrid Rat Cytochrome P450 Containing the First 5 Exons of the CYP11B1 and Last 4 Exons from the CYP11B2 Enzyme Retains 11β-Hydroxylase Activity, but the Alternative Hybrid Is Inactive" @default.
- W2064204240 doi "https://doi.org/10.1006/bbrc.1994.1204" @default.
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