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• W2064204410 endingPage "14132" @default.
• W2064204410 startingPage "14127" @default.
• W2064204410 abstract "Cotranslational N-glycosylation can accelerate protein folding, slow protein unfolding, and increase protein stability, but the molecular basis for these energetic effects is incompletely understood. N-glycosylation of proteins at naïve sites could be a useful strategy for stabilizing proteins in therapeutic and research applications, but without engineering guidelines, often results in unpredictable changes to protein energetics. We recently introduced the enhanced aromatic sequon as a family of portable structural motifs that are stabilized upon glycosylation in specific reverse turn contexts: a five-residue type I β-turn harboring a G1 β-bulge (using a Phe-Yyy-Asn-Xxx-Thr sequon) and a type II β-turn within a six-residue loop (using a Phe-Yyy-Zzz-Asn-Xxx-Thr sequon) [Culyba EK, et al. (2011) Science 331:571-575]. Here we show that glycosylating a new enhanced aromatic sequon, Phe-Asn-Xxx-Thr, in a type I' β-turn stabilizes the Pin 1 WW domain. Comparing the energetic effects of glycosylating these three enhanced aromatic sequons in the same host WW domain revealed that the glycosylation-mediated stabilization is greatest for the enhanced aromatic sequon complementary to the type I β-turn with a G1 β-bulge. However, the portion of the stabilization from the tripartite interaction between Phe, Asn(GlcNAc), and Thr is similar for each enhanced aromatic sequon in its respective reverse turn context. Adding the Phe-Asn-Xxx-Thr motif (in a type I' β-turn) to the enhanced aromatic sequon family doubles the number of proteins that can be stabilized by glycosylation without having to alter the native reverse turn type." @default.
• W2064204410 created "2016-06-24" @default.
• W2064204410 creator A5058937449 @default.
• W2064204410 creator A5073572665 @default.
• W2064204410 creator A5081499831 @default.
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• W2064204410 date "2011-08-08" @default.
• W2064204410 modified "2023-10-16" @default.
• W2064204410 title "Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts" @default.
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• W2064204410 doi "https://doi.org/10.1073/pnas.1105880108" @default.
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