Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064210857> ?p ?o ?g. }
- W2064210857 endingPage "e75118" @default.
- W2064210857 startingPage "e75118" @default.
- W2064210857 abstract "Sub-therapeutic and supra-therapeutic plasma concentrations of antriretrovirals are the significant causes of treatment failure and toxicity respectively among HIV-infected patients. We conducted this study to determine the pattern of efavirenz and nevirapine plasma drug concentrations among adult HIV-infected patients with immunological failure attending at a tertiary hospital in North-western Tanzania.A cross-sectional study was conducted among adult HIV-infected patients with immunological failure who have been on either efavirenz or nevirapine based antiretroviral regimen for more than 6 months. Patients were serially enrolled through routine Care and Treatment Clinic (CTC) activities. Plasma drug concentrations for efavirenz and nevirapine were determined by high performance liquid chromatography (HPLC) and Gas Chromatography (GC) respectively. Demographic, clinical and laboratory data such as viral load and CD4 counts were collected. Data analysis was done using STATA 12.Of the 152 patients with immunological failure enrolled, the sub-therapeutic, therapeutic and supra-therapeutic plasma antiretroviral drug concentrations were found in 43/152 (28.3%), 76/152 (50.0%) and 33/152 (21.7%) respectively. Half of the patients were outside therapeutic window with either sub-therapeutic or supra-therapeutic plasma ARV drug concentrations. There was a significant difference in distribution of ARV adherence (p-value<0.001), NRTI backbone (p-value = 0.039), HIV stage (p-value = 0.026) and viral load (p-value = 0.007) within sub-therapeutic, therapeutic and supra-therapeutic ARV plasma drug concentrations.There is a wide inter-individual variability of plasma ARV concentrations among HIV patients with immunological failure, with a large proportion of patients being outside therapeutic window. This variability is significant based on ARV adherence, NRTI backbone, viral load and HIV stage. Routine therapeutic drug monitoring (TDM) could assist identifying these patients early and making timely correction to avoid virological failure, poor immunological outcome and prevent associated drug toxicities. Nonetheless, ARV adherence should be strictly emphasized on HIV patients with immunological failure." @default.
- W2064210857 created "2016-06-24" @default.
- W2064210857 creator A5013929805 @default.
- W2064210857 creator A5037590928 @default.
- W2064210857 creator A5041408009 @default.
- W2064210857 creator A5049722680 @default.
- W2064210857 creator A5049829595 @default.
- W2064210857 creator A5050459125 @default.
- W2064210857 creator A5082060037 @default.
- W2064210857 creator A5086760804 @default.
- W2064210857 creator A5091425909 @default.
- W2064210857 date "2013-09-10" @default.
- W2064210857 modified "2023-09-24" @default.
- W2064210857 title "Plasma Concentrations of Efavirenz and Nevirapine among HIV-Infected Patients with Immunological Failure Attending a Tertiary Hospital in North-Western Tanzania" @default.
- W2064210857 cites W1533109276 @default.
- W2064210857 cites W178626500 @default.
- W2064210857 cites W1976975094 @default.
- W2064210857 cites W1979125889 @default.
- W2064210857 cites W1979933761 @default.
- W2064210857 cites W2004353492 @default.
- W2064210857 cites W2008565853 @default.
- W2064210857 cites W2008579529 @default.
- W2064210857 cites W2011013717 @default.
- W2064210857 cites W2018852632 @default.
- W2064210857 cites W2026219081 @default.
- W2064210857 cites W2042830298 @default.
- W2064210857 cites W2055552960 @default.
- W2064210857 cites W2059566597 @default.
- W2064210857 cites W2064510625 @default.
- W2064210857 cites W2066525177 @default.
- W2064210857 cites W2071067871 @default.
- W2064210857 cites W2081935668 @default.
- W2064210857 cites W2087829259 @default.
- W2064210857 cites W2092560735 @default.
- W2064210857 cites W2106737113 @default.
- W2064210857 cites W2127096996 @default.
- W2064210857 cites W2130447065 @default.
- W2064210857 cites W2135892517 @default.
- W2064210857 cites W2139393856 @default.
- W2064210857 cites W2144905510 @default.
- W2064210857 cites W2318289184 @default.
- W2064210857 cites W4367486924 @default.
- W2064210857 doi "https://doi.org/10.1371/journal.pone.0075118" @default.
- W2064210857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3769243" @default.
- W2064210857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24058655" @default.
- W2064210857 hasPublicationYear "2013" @default.
- W2064210857 type Work @default.
- W2064210857 sameAs 2064210857 @default.
- W2064210857 citedByCount "19" @default.
- W2064210857 countsByYear W20642108572014 @default.
- W2064210857 countsByYear W20642108572015 @default.
- W2064210857 countsByYear W20642108572016 @default.
- W2064210857 countsByYear W20642108572017 @default.
- W2064210857 countsByYear W20642108572018 @default.
- W2064210857 countsByYear W20642108572019 @default.
- W2064210857 countsByYear W20642108572020 @default.
- W2064210857 countsByYear W20642108572021 @default.
- W2064210857 countsByYear W20642108572022 @default.
- W2064210857 crossrefType "journal-article" @default.
- W2064210857 hasAuthorship W2064210857A5013929805 @default.
- W2064210857 hasAuthorship W2064210857A5037590928 @default.
- W2064210857 hasAuthorship W2064210857A5041408009 @default.
- W2064210857 hasAuthorship W2064210857A5049722680 @default.
- W2064210857 hasAuthorship W2064210857A5049829595 @default.
- W2064210857 hasAuthorship W2064210857A5050459125 @default.
- W2064210857 hasAuthorship W2064210857A5082060037 @default.
- W2064210857 hasAuthorship W2064210857A5086760804 @default.
- W2064210857 hasAuthorship W2064210857A5091425909 @default.
- W2064210857 hasBestOaLocation W20642108571 @default.
- W2064210857 hasConcept C102652120 @default.
- W2064210857 hasConcept C112705442 @default.
- W2064210857 hasConcept C126322002 @default.
- W2064210857 hasConcept C142462285 @default.
- W2064210857 hasConcept C19831878 @default.
- W2064210857 hasConcept C203014093 @default.
- W2064210857 hasConcept C2779130552 @default.
- W2064210857 hasConcept C2780035454 @default.
- W2064210857 hasConcept C2780272996 @default.
- W2064210857 hasConcept C2781413609 @default.
- W2064210857 hasConcept C2781432083 @default.
- W2064210857 hasConcept C2993143319 @default.
- W2064210857 hasConcept C3013748606 @default.
- W2064210857 hasConcept C71924100 @default.
- W2064210857 hasConcept C98274493 @default.
- W2064210857 hasConceptScore W2064210857C102652120 @default.
- W2064210857 hasConceptScore W2064210857C112705442 @default.
- W2064210857 hasConceptScore W2064210857C126322002 @default.
- W2064210857 hasConceptScore W2064210857C142462285 @default.
- W2064210857 hasConceptScore W2064210857C19831878 @default.
- W2064210857 hasConceptScore W2064210857C203014093 @default.
- W2064210857 hasConceptScore W2064210857C2779130552 @default.
- W2064210857 hasConceptScore W2064210857C2780035454 @default.
- W2064210857 hasConceptScore W2064210857C2780272996 @default.
- W2064210857 hasConceptScore W2064210857C2781413609 @default.
- W2064210857 hasConceptScore W2064210857C2781432083 @default.
- W2064210857 hasConceptScore W2064210857C2993143319 @default.
- W2064210857 hasConceptScore W2064210857C3013748606 @default.
- W2064210857 hasConceptScore W2064210857C71924100 @default.