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- W2064248618 abstract "In addition to regulating reproductive functions in the brain and periphery, estrogen has tropic and neuroprotective functions in the central nervous system (CNS). Estrogen administration has been demonstrated to provide protection in several animal models of CNS disorders, including stroke, brain injury, epilepsy, Parkinson's disease, Alzheimer's disease, age-related cognitive decline and multiple sclerosis. Here, we use a model of toxin-induced oligodendrocyte death which results in demyelination, reactive gliosis, recruitment of oligodendrocyte precursor cells and subsequent remyelination to study the potential benefit of 17β-estradiol (E2) administration in male mice. The results indicate that E2 partially ameliorates loss of oligodendrocytes and demyelination in the corpus callosum. This protection is accompanied by a delay in microglia accumulation as well as reduced mRNA expression of the pro-inflammatory cytokine, tumor necrosis factor alpha (TNFα), and insulin-like growth factor-1 (IGF-1). E2 did not significantly alter the accumulation of astrocytes or oligodendrocyte precursor cells, or remyelination. These data obtained from a toxin-induced, T cell-independent model using male mice provide an expanded view of the beneficial effects of estrogen on oligodendrocyte and myelin preservation." @default.
- W2064248618 created "2016-06-24" @default.
- W2064248618 creator A5021145558 @default.
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- W2064248618 creator A5049638009 @default.
- W2064248618 creator A5066660635 @default.
- W2064248618 creator A5075107508 @default.
- W2064248618 date "2010-08-01" @default.
- W2064248618 modified "2023-10-15" @default.
- W2064248618 title "17β-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss" @default.
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- W2064248618 doi "https://doi.org/10.1016/j.nbd.2010.03.016" @default.
- W2064248618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2891426" @default.
- W2064248618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20347981" @default.
- W2064248618 hasPublicationYear "2010" @default.
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