FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064252404> ?p ?o ?g. }

• W2064252404 endingPage "51" @default.
• W2064252404 startingPage "41" @default.
• W2064252404 abstract "Three series of studies were conducted to specify the role of 5-HT1A receptors in memory; using selective ligands that differentially activate 5-HT1A receptors, it was determined whether a change in the activation state of these receptors can lead to deficient retrieval, and whether a so-produced deficit can occur in an animal model of depression. First, in vitro studies of [35S]GTPγS binding responses identified ligands that differentially activate 5-HT1A receptors in rat hippocampus. WAY 100635, 8-OH-DPAT and flesinoxan induced 5-HT1A receptor activation that amounted to −2, +50 and +63%, respectively, of that produced by 5-HT. Second, we determined whether changes in the activation state of 5-HT1A receptors could impair the retrieval of an operant response in vivo. Rats treated with either a 5-HT1A receptor ligand or saline were trained to lever press for milk reward, and were then tested for retrieval with either the same or another treatment. Animals trained with 8-OH-DPAT retrieved the response when tested in the same state, but not when tested in the saline state, and vice versa. Rats trained with 0.16 mg/kg of 8-OH-DPAT also retrieved the response when tested with the other intermediate-efficacy ligand flesinoxan (0.63 mg/kg), but not when tested in a state of lower-magnitude activation (i.e. with 0.16 mg/kg of WAY 100635). Animals trained with 0.16 mg/kg of WAY 100635 retrieved the response when tested in this same state or with saline, but not when tested in a state of intermediate-magnitude activation (i.e. with 0.16 mg/kg of 8-OH-DPAT). Finally, studies using the forced swimming paradigm indicated that the retrieval of learned immobility was similarly dependent upon the activation state of 5-HT1A receptors. The findings indicate that changes in activation states of 5-HT1A receptors can impair the retrieval of learned responses. It is suggested that depression may in part be acquired in the course of ontogeny and may be available for retrieval in the same but not in other states; various biological rhythms conceivably define such states." @default.
• W2064252404 created "2016-06-24" @default.
• W2064252404 creator A5000070208 @default.
• W2064252404 creator A5035103700 @default.
• W2064252404 creator A5080164174 @default.
• W2064252404 creator A5083537506 @default.
• W2064252404 date "2000-12-01" @default.
• W2064252404 modified "2023-10-02" @default.
• W2064252404 title "Memory of an operant response and of depressed mood retained in activation states of 5-HT1A receptors: evidence from rodent models" @default.
• W2064252404 cites W107475310 @default.
• W2064252404 cites W148264696 @default.
• W2064252404 cites W1505185418 @default.
• W2064252404 cites W1515279996 @default.
• W2064252404 cites W1548569021 @default.
• W2064252404 cites W1965507891 @default.
• W2064252404 cites W1965578008 @default.
• W2064252404 cites W1966327473 @default.
• W2064252404 cites W1972882218 @default.
• W2064252404 cites W1973386992 @default.
• W2064252404 cites W1974282564 @default.
• W2064252404 cites W1975047745 @default.
• W2064252404 cites W1975198366 @default.
• W2064252404 cites W1977602105 @default.
• W2064252404 cites W1978402439 @default.
• W2064252404 cites W1978477157 @default.
• W2064252404 cites W1979017418 @default.
• W2064252404 cites W1982293321 @default.
• W2064252404 cites W1982481286 @default.
• W2064252404 cites W1984575283 @default.
• W2064252404 cites W1988375813 @default.
• W2064252404 cites W1988978158 @default.
• W2064252404 cites W1993208043 @default.
• W2064252404 cites W1996337988 @default.
• W2064252404 cites W1996636065 @default.
• W2064252404 cites W1997880998 @default.
• W2064252404 cites W1999226033 @default.
• W2064252404 cites W2001196038 @default.
• W2064252404 cites W2002671738 @default.
• W2064252404 cites W2007519187 @default.
• W2064252404 cites W2008440476 @default.
• W2064252404 cites W2011438483 @default.
• W2064252404 cites W2016888719 @default.
• W2064252404 cites W2017169966 @default.
• W2064252404 cites W2021624093 @default.
• W2064252404 cites W2025614347 @default.
• W2064252404 cites W2038542576 @default.
• W2064252404 cites W2039022088 @default.
• W2064252404 cites W2039453452 @default.
• W2064252404 cites W2050836998 @default.
• W2064252404 cites W2052194813 @default.
• W2064252404 cites W2054139765 @default.
• W2064252404 cites W2058760081 @default.
• W2064252404 cites W2061640164 @default.
• W2064252404 cites W2063038095 @default.
• W2064252404 cites W2064318171 @default.
• W2064252404 cites W2064742857 @default.
• W2064252404 cites W2067727218 @default.
• W2064252404 cites W2068405118 @default.
• W2064252404 cites W2069566702 @default.
• W2064252404 cites W2075434858 @default.
• W2064252404 cites W2076453858 @default.
• W2064252404 cites W2076834716 @default.
• W2064252404 cites W2078060255 @default.
• W2064252404 cites W2080649078 @default.
• W2064252404 cites W2081168294 @default.
• W2064252404 cites W2086393860 @default.
• W2064252404 cites W2092686956 @default.
• W2064252404 cites W2094469890 @default.
• W2064252404 cites W2094569992 @default.
• W2064252404 cites W2111560916 @default.
• W2064252404 cites W2125079713 @default.
• W2064252404 cites W2153474878 @default.
• W2064252404 cites W2184628412 @default.
• W2064252404 cites W2408969546 @default.
• W2064252404 cites W2477072365 @default.
• W2064252404 cites W2498146841 @default.
• W2064252404 cites W2506121317 @default.
• W2064252404 cites W4237434378 @default.
• W2064252404 cites W4238215630 @default.
• W2064252404 cites W4245426200 @default.
• W2064252404 cites W4246724958 @default.
• W2064252404 cites W4251235114 @default.
• W2064252404 cites W4293247451 @default.
• W2064252404 cites W4294351883 @default.
• W2064252404 doi "https://doi.org/10.1016/s0166-4328(00)00283-7" @default.
• W2064252404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11099756" @default.
• W2064252404 hasPublicationYear "2000" @default.
• W2064252404 type Work @default.
• W2064252404 sameAs 2064252404 @default.
• W2064252404 citedByCount "10" @default.
• W2064252404 countsByYear W20642524042012 @default.
• W2064252404 countsByYear W20642524042014 @default.
• W2064252404 countsByYear W20642524042023 @default.
• W2064252404 crossrefType "journal-article" @default.
• W2064252404 hasAuthorship W2064252404A5000070208 @default.
• W2064252404 hasAuthorship W2064252404A5035103700 @default.
• W2064252404 hasAuthorship W2064252404A5080164174 @default.
• W2064252404 hasAuthorship W2064252404A5083537506 @default.

• next