FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064265775> ?p ?o ?g. }

• W2064265775 endingPage "162" @default.
• W2064265775 startingPage "151" @default.
• W2064265775 abstract "The idea that luminal Na + can regulate epithelial Na + channels was tested in the cortical collecting tubule of the rat using whole‐cell and single‐channel recordings. Here we report results consistent with the idea of Na + self‐inhibition. Macroscopic amiloride‐sensitive currents ( I Na ) were measured by conventional whole‐cell clamp. I Na was a saturable function of external Na + concentration ([Na + ] o ) with an apparent K m of 9 m m . Single channel currents ( i Na ) were measured in cell‐attached patches. i Na increased with pipette Na + concentration with an apparent K m of 48 m m . Since I Na = ( i Na ) NP o , the different K m values imply that the channel density ( N ) and/or open probability ( P o ) increase as [Na + ] o decreases. Reduction of [Na + ] o after increasing intracellular Na + concentration also increased the outward amiloride‐sensitive conductance, consistent with activation of the Na + channels. The underlying mechanism was studied by changing pipette Na + concentration while recording from cell‐attached patches. No increase in NP o was observed, suggesting that the effect is not a direct interaction between [Na + ] o and the channel. [Na + ] o was varied outside the patch‐clamp pipette while recording from cell‐attached patches. When amiloride was in the bath to prevent Na + entry, no change in NP o was observed. Activation of the channels by hyperpolarization was observed with 140 m m Na + o but not with 14 m m Na + o . The results are consistent with the concept of self‐inhibition of Na + channels by luminal Na + . Activation of the channels by lowering [Na + ] o is not additive with that achieved by hyperpolarization." @default.
• W2064265775 created "2016-06-24" @default.
• W2064265775 creator A5048035994 @default.
• W2064265775 creator A5075080903 @default.
• W2064265775 creator A5089954997 @default.
• W2064265775 date "1998-05-01" @default.
• W2064265775 modified "2023-10-15" @default.
• W2064265775 title "Regulation of Na⁺channels by luminal Na⁺in rat cortical collecting tubule" @default.
• W2064265775 cites W1606227954 @default.
• W2064265775 cites W1970084641 @default.
• W2064265775 cites W1970701365 @default.
• W2064265775 cites W1971849369 @default.
• W2064265775 cites W2018499368 @default.
• W2064265775 cites W2043643098 @default.
• W2064265775 cites W2053496952 @default.
• W2064265775 cites W2060838963 @default.
• W2064265775 cites W2098549342 @default.
• W2064265775 cites W2103252057 @default.
• W2064265775 cites W2115009943 @default.
• W2064265775 cites W2126076477 @default.
• W2064265775 cites W2131350335 @default.
• W2064265775 cites W2161566500 @default.
• W2064265775 cites W2278677366 @default.
• W2064265775 cites W2279422544 @default.
• W2064265775 cites W2302511111 @default.
• W2064265775 cites W2399166644 @default.
• W2064265775 cites W2402109478 @default.
• W2064265775 cites W2406381637 @default.
• W2064265775 cites W2408306605 @default.
• W2064265775 cites W2410938821 @default.
• W2064265775 cites W2411122377 @default.
• W2064265775 cites W2441237206 @default.
• W2064265775 cites W2460042962 @default.
• W2064265775 cites W2466773475 @default.
• W2064265775 doi "https://doi.org/10.1111/j.1469-7793.1998.151bo.x" @default.
• W2064265775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2230952" @default.
• W2064265775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9547389" @default.
• W2064265775 hasPublicationYear "1998" @default.
• W2064265775 type Work @default.
• W2064265775 sameAs 2064265775 @default.
• W2064265775 citedByCount "63" @default.
• W2064265775 countsByYear W20642657752012 @default.
• W2064265775 countsByYear W20642657752013 @default.
• W2064265775 countsByYear W20642657752015 @default.
• W2064265775 countsByYear W20642657752016 @default.
• W2064265775 countsByYear W20642657752017 @default.
• W2064265775 countsByYear W20642657752020 @default.
• W2064265775 countsByYear W20642657752021 @default.
• W2064265775 countsByYear W20642657752022 @default.
• W2064265775 crossrefType "journal-article" @default.
• W2064265775 hasAuthorship W2064265775A5048035994 @default.
• W2064265775 hasAuthorship W2064265775A5075080903 @default.
• W2064265775 hasAuthorship W2064265775A5089954997 @default.
• W2064265775 hasBestOaLocation W20642657751 @default.
• W2064265775 hasConcept C113196181 @default.
• W2064265775 hasConcept C121332964 @default.
• W2064265775 hasConcept C121932024 @default.
• W2064265775 hasConcept C12554922 @default.
• W2064265775 hasConcept C131453863 @default.
• W2064265775 hasConcept C147789679 @default.
• W2064265775 hasConcept C147944092 @default.
• W2064265775 hasConcept C151552171 @default.
• W2064265775 hasConcept C170493617 @default.
• W2064265775 hasConcept C178790620 @default.
• W2064265775 hasConcept C185592680 @default.
• W2064265775 hasConcept C26873012 @default.
• W2064265775 hasConcept C2778071365 @default.
• W2064265775 hasConcept C2779608910 @default.
• W2064265775 hasConcept C43617362 @default.
• W2064265775 hasConcept C537181965 @default.
• W2064265775 hasConcept C55493867 @default.
• W2064265775 hasConcept C6507245 @default.
• W2064265775 hasConcept C66974803 @default.
• W2064265775 hasConcept C71240020 @default.
• W2064265775 hasConcept C79879829 @default.
• W2064265775 hasConcept C86803240 @default.
• W2064265775 hasConceptScore W2064265775C113196181 @default.
• W2064265775 hasConceptScore W2064265775C121332964 @default.
• W2064265775 hasConceptScore W2064265775C121932024 @default.
• W2064265775 hasConceptScore W2064265775C12554922 @default.
• W2064265775 hasConceptScore W2064265775C131453863 @default.
• W2064265775 hasConceptScore W2064265775C147789679 @default.
• W2064265775 hasConceptScore W2064265775C147944092 @default.
• W2064265775 hasConceptScore W2064265775C151552171 @default.
• W2064265775 hasConceptScore W2064265775C170493617 @default.
• W2064265775 hasConceptScore W2064265775C178790620 @default.
• W2064265775 hasConceptScore W2064265775C185592680 @default.
• W2064265775 hasConceptScore W2064265775C26873012 @default.
• W2064265775 hasConceptScore W2064265775C2778071365 @default.
• W2064265775 hasConceptScore W2064265775C2779608910 @default.
• W2064265775 hasConceptScore W2064265775C43617362 @default.
• W2064265775 hasConceptScore W2064265775C537181965 @default.
• W2064265775 hasConceptScore W2064265775C55493867 @default.
• W2064265775 hasConceptScore W2064265775C6507245 @default.
• W2064265775 hasConceptScore W2064265775C66974803 @default.
• W2064265775 hasConceptScore W2064265775C71240020 @default.
• W2064265775 hasConceptScore W2064265775C79879829 @default.
• W2064265775 hasConceptScore W2064265775C86803240 @default.

• next