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- W2064269310 abstract "The 12 bp stem of the RNA hairpin responsible for the gag-pol frameshifting of the ribosomes during translation of the polycistronic HIV-1 mRNA has a pyrimidine-rich 5′ strand and, consequently, a purine-rich 3′ strand. Electrophoretic mobility shift assays have shown that DNA oligopyrimidines, 12 and 20 nucleotides long (but not oligopurines or G,T-containing oligomers), designed to form triplexes actually bind to the double-stranded RNA target. RNase V1 footprinting studies have confirmed the interaction between the hairpin stem and the. RNA and 2′-O-methyl oligoribonucleotide analogues of the 12-mer oligodeoxypyrimidine as well as 5 propynyl,cytosine, containing the 12-mer oligodeoxypyrimidine, bind more strongly to the RNA target than the unmodified parent DNA oligomer. The complexes formed by the RNA hairpin and either the 12-mer oligodeoxypyrimidine or the 20-mer oligopyrimidine are stable at a neutral pH and in the absence of Mg2+ but blocked neither the reverse transcription nor cell-free translation of a RNA template in which the gag-pol frameshifting hairpin was inserted at the 5′ end of the luciferase open reading frame." @default.
- W2064269310 created "2016-06-24" @default.
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- W2064269310 date "1999-04-23" @default.
- W2064269310 modified "2023-09-26" @default.
- W2064269310 title "Binding of oligopyrimidines to the RNA hairpin responsible for the ribosome<i>gag-pol</i>frameshift in HIV-1" @default.
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- W2064269310 doi "https://doi.org/10.1016/s0014-5793(99)00427-5" @default.
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