FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064271237> ?p ?o ?g. }

• W2064271237 endingPage "189" @default.
• W2064271237 startingPage "183" @default.
• W2064271237 abstract "We have previously demonstrated that antigens chemically coupled to the surface of liposomes consisting of unsaturated fatty acids were cross-presented by antigen presenting cells to cytotoxic T lymphocytes (CTLs). Liposomal form of immunodominant CTL epitope peptides derived from lymphocytic choriomeningitis virus exhibited highly efficient antiviral CTL responses in immunized mice. In this study, we coupled 15 highly conserved immunodominant CTL epitope peptides derived from hepatitis C virus (HCV) to the surface of liposomes. We also emulsified the peptides in incomplete Freund's adjuvant, and compared the immune responses of the two methods of presenting the peptides by cytotoxicity induction and interferon-gamma (IFN-γ) production by CD8(+) T cells of the immunized mice. We noticed significant variations of the immunogenicity of each peptide between the two antigen delivery systems. In addition, the immunogenicity profiles of the peptides were also different from those observed in the mice infected with recombinant adenoviruses expressing HCV proteins as previously reported. Induction of anti-viral immunity by liposomal peptides was tested by the challenge experiments using recombinant vaccinia viruses expressing corresponding HCV epitopes. One D(b)-restricted and three HLA-A(*)0201-restricted HCV CTL epitope peptides on the surface of liposomes were found to confer complete protection to immunized mice with establishment of long-term memory. Interestingly, their protective efficacy seemed to correlate with the induction of IFN-γ producing cells rather than the cytotoxicity induction suggesting that the immunized mice were protected through non-cytolytic mechanisms. Thus, these liposomal peptides might be useful as HCV vaccines not only for prevention but also for therapeutic use." @default.
• W2064271237 created "2016-06-24" @default.
• W2064271237 creator A5004757783 @default.
• W2064271237 creator A5014819197 @default.
• W2064271237 creator A5029539450 @default.
• W2064271237 creator A5038160810 @default.
• W2064271237 creator A5052670145 @default.
• W2064271237 date "2013-01-01" @default.
• W2064271237 modified "2023-10-14" @default.
• W2064271237 title "Coupling to the surface of liposomes alters the immunogenicity of hepatitis C virus-derived peptides and confers sterile immunity" @default.
• W2064271237 cites W1830381528 @default.
• W2064271237 cites W1949623051 @default.
• W2064271237 cites W1968439321 @default.
• W2064271237 cites W1970785321 @default.
• W2064271237 cites W1973165481 @default.
• W2064271237 cites W1983222052 @default.
• W2064271237 cites W2006599744 @default.
• W2064271237 cites W2028488167 @default.
• W2064271237 cites W2039800389 @default.
• W2064271237 cites W2045562270 @default.
• W2064271237 cites W2046850243 @default.
• W2064271237 cites W2052325775 @default.
• W2064271237 cites W2052915357 @default.
• W2064271237 cites W2071911570 @default.
• W2064271237 cites W2075287837 @default.
• W2064271237 cites W2077354648 @default.
• W2064271237 cites W2080757497 @default.
• W2064271237 cites W2082059373 @default.
• W2064271237 cites W2106576594 @default.
• W2064271237 cites W2111359040 @default.
• W2064271237 cites W2138205821 @default.
• W2064271237 cites W2164783799 @default.
• W2064271237 doi "https://doi.org/10.1016/j.bbrc.2012.11.028" @default.
• W2064271237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7124229" @default.
• W2064271237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23159619" @default.
• W2064271237 hasPublicationYear "2013" @default.
• W2064271237 type Work @default.
• W2064271237 sameAs 2064271237 @default.
• W2064271237 citedByCount "10" @default.
• W2064271237 countsByYear W20642712372014 @default.
• W2064271237 countsByYear W20642712372015 @default.
• W2064271237 countsByYear W20642712372016 @default.
• W2064271237 countsByYear W20642712372017 @default.
• W2064271237 countsByYear W20642712372018 @default.
• W2064271237 countsByYear W20642712372021 @default.
• W2064271237 countsByYear W20642712372022 @default.
• W2064271237 countsByYear W20642712372023 @default.
• W2064271237 crossrefType "journal-article" @default.
• W2064271237 hasAuthorship W2064271237A5004757783 @default.
• W2064271237 hasAuthorship W2064271237A5014819197 @default.
• W2064271237 hasAuthorship W2064271237A5029539450 @default.
• W2064271237 hasAuthorship W2064271237A5038160810 @default.
• W2064271237 hasAuthorship W2064271237A5052670145 @default.
• W2064271237 hasBestOaLocation W20642712371 @default.
• W2064271237 hasConcept C104317684 @default.
• W2064271237 hasConcept C147483822 @default.
• W2064271237 hasConcept C147969180 @default.
• W2064271237 hasConcept C154317977 @default.
• W2064271237 hasConcept C159047783 @default.
• W2064271237 hasConcept C167672396 @default.
• W2064271237 hasConcept C195616568 @default.
• W2064271237 hasConcept C202751555 @default.
• W2064271237 hasConcept C203014093 @default.
• W2064271237 hasConcept C2522874641 @default.
• W2064271237 hasConcept C2777863537 @default.
• W2064271237 hasConcept C2780868878 @default.
• W2064271237 hasConcept C2781356689 @default.
• W2064271237 hasConcept C40767141 @default.
• W2064271237 hasConcept C55493867 @default.
• W2064271237 hasConcept C86803240 @default.
• W2064271237 hasConcept C8891405 @default.
• W2064271237 hasConceptScore W2064271237C104317684 @default.
• W2064271237 hasConceptScore W2064271237C147483822 @default.
• W2064271237 hasConceptScore W2064271237C147969180 @default.
• W2064271237 hasConceptScore W2064271237C154317977 @default.
• W2064271237 hasConceptScore W2064271237C159047783 @default.
• W2064271237 hasConceptScore W2064271237C167672396 @default.
• W2064271237 hasConceptScore W2064271237C195616568 @default.
• W2064271237 hasConceptScore W2064271237C202751555 @default.
• W2064271237 hasConceptScore W2064271237C203014093 @default.
• W2064271237 hasConceptScore W2064271237C2522874641 @default.
• W2064271237 hasConceptScore W2064271237C2777863537 @default.
• W2064271237 hasConceptScore W2064271237C2780868878 @default.
• W2064271237 hasConceptScore W2064271237C2781356689 @default.
• W2064271237 hasConceptScore W2064271237C40767141 @default.
• W2064271237 hasConceptScore W2064271237C55493867 @default.
• W2064271237 hasConceptScore W2064271237C86803240 @default.
• W2064271237 hasConceptScore W2064271237C8891405 @default.
• W2064271237 hasIssue "1" @default.
• W2064271237 hasLocation W20642712371 @default.
• W2064271237 hasLocation W20642712372 @default.
• W2064271237 hasLocation W20642712373 @default.
• W2064271237 hasLocation W20642712374 @default.
• W2064271237 hasOpenAccess W2064271237 @default.
• W2064271237 hasPrimaryLocation W20642712371 @default.
• W2064271237 hasRelatedWork W1024660077 @default.
• W2064271237 hasRelatedWork W1481917790 @default.
• W2064271237 hasRelatedWork W2006327952 @default.

• next