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- W2064280218 abstract "The human leukocyte antigen (HLA) system could play an essential role in multiple myeloma (MM) disease control. This report describes the results comparing HLA-DRB1 phenotypic frequencies in 181 MM patients (53 smoldering/indolent MM and 128 symptomatic MM patients) and healthy individuals. Higher DRB1*01 phenotypic frequencies were found in the smoldering patients compared with symptomatic MM patients (38% vs 14%, P = 0.001) and with the healthy individuals (38% vs 22%, P = 0.01). Additionally, higher DRB1*07 phenotypic frequencies were found in symptomatic MM compared with control population (38% vs 28%, P = 0.01). The present data suggest that HLA-DRB1*01 individuals may have a better ability to efficiently present myeloma-related antigens to immunocompetent cells, which could favor a better immune response against the tumor. This would translate into a more appropriate disease control associated with more indolent disease and prolonged survival." @default.
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- W2064280218 date "2008-06-01" @default.
- W2064280218 modified "2023-10-14" @default.
- W2064280218 title "The presence of DRB1*01 allele in multiple myeloma patients is associated with an indolent disease" @default.
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- W2064280218 doi "https://doi.org/10.1111/j.1399-0039.2008.01048.x" @default.
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