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- W2064284877 abstract "Four Australian strains of infectious bovine rhinotracheitis (IBR) herpesvirus, isolated from rhinitis, vulvovaginitis and meningo-encephalitis were examined. In experimental calves, all strains of virus produced rhinitis, conjunctivitis and vulvovaginitis when applied to these surfaces, but only the isolate from meningo-encephalitis (N569) produced a fatal meningo-encephalitis after intranasal infection and a meningitis-like disease after intravaginal infection. N569 virus instilled on the conjunctiva produced a temperature rise and virus proliferation in the nasal cavity, but not meningo-encephalitis. Pre-existing serum neutralizing antibody to heterologous strains of IBR virus protected calves challenged intranasally with N569 virus. The 4 strains of IBR virus showed no differences in thermostability at 40°C. or in buoyant density of infectious particles, but the N569 strain formed smaller plaques under agar overlay. Rabbit hyperimmune serums produced against each virus strain detected no antigenic differences between isolates from rhinitis and vulvovaginitis, but the antigenic nature of N569 virus was significantly different (P < 0·05) from the other 3 strains of IBR virus." @default.
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- W2064284877 date "1972-10-01" @default.
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- W2064284877 title "Comparison of the biological, biophysical and antigenic properties of four strains of infectious bovine rhinotracheitis herpesvirus" @default.
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- W2064284877 doi "https://doi.org/10.1016/0021-9975(72)90035-7" @default.
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