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- W2064284932 endingPage "E137" @default.
- W2064284932 startingPage "E126" @default.
- W2064284932 abstract "The cloning of the opioid receptors and subsequent use of recombinant DNA technology have led to many new insights into ligand binding. Instead of focusing on the structural features that lead to increased affinity and selectivity, researchers are now able to focus on why these features are important. Site-directed mutagenesis and chimeric data have often been at the forefront in answering these questions. Herein, we survey pharmacophores of several opioid ligands in an effort to understand the structural requirements for ligand binding and selectivity. Models are presented and compared to illustrate key sites of recognition for both opiate and nonopiate ligands. The results indicate that different ligand classes may recognize different sites within the receptor, suggesting that multiple epitopes may exist for ligand binding and selectivity." @default.
- W2064284932 created "2016-06-24" @default.
- W2064284932 creator A5074917182 @default.
- W2064284932 creator A5078796555 @default.
- W2064284932 creator A5086683892 @default.
- W2064284932 date "2006-03-01" @default.
- W2064284932 modified "2023-10-16" @default.
- W2064284932 title "Molecular recognition of opioid receptor ligands" @default.
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- W2064284932 doi "https://doi.org/10.1208/aapsj080115" @default.
- W2064284932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2751431" @default.
- W2064284932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16584119" @default.
- W2064284932 hasPublicationYear "2006" @default.
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