Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064287695> ?p ?o ?g. }
- W2064287695 endingPage "280" @default.
- W2064287695 startingPage "274" @default.
- W2064287695 abstract "We report here design of a graphene oxide-based electrochemical biosensor for detection of platelet-derived microparticles (PMPs), a major risk factor for arterial pro-thrombotic pathologies like acute myocardial infarction and stroke. Electrodes were fabricated with immobilized layers of graphene oxide and a specific antibody targeted against active conformation of integrin αIIbβ3 on PMP surface. Results showed progressive rise in impedance in Nyquist plots with increasing number of PMPs in analyte. The sensor was highly specific for PMPs and did not identify microparticles originating from other cells. Blood obtained from patients diagnosed with acute myocardial infarction exhibited significantly higher values of impedance, consistent with larger number of circulating PMPs in these patients, as compared to samples from healthy individuals, thus validating biosensor as a specific, sensitive, label-free and cost-effective tool for rapid point-of-care detection of PMPs at bedside. Our biosensor is most ideal for mass population screening programs at periphery-level healthcare units with limited resources. It is aimed at early detection of individuals having higher imminent cardiovascular risk, as well as for routine analysis, which in turn would contribute to better management and survival of screened 'high-risk' subjects." @default.
- W2064287695 created "2016-06-24" @default.
- W2064287695 creator A5000779585 @default.
- W2064287695 creator A5006779868 @default.
- W2064287695 creator A5025546371 @default.
- W2064287695 creator A5044867217 @default.
- W2064287695 creator A5065586922 @default.
- W2064287695 date "2015-03-01" @default.
- W2064287695 modified "2023-10-17" @default.
- W2064287695 title "Graphene oxide-based biosensor for detection of platelet-derived microparticles: A potential tool for thrombus risk identification" @default.
- W2064287695 cites W1693284829 @default.
- W2064287695 cites W1911872793 @default.
- W2064287695 cites W1979861324 @default.
- W2064287695 cites W1989152454 @default.
- W2064287695 cites W1997860246 @default.
- W2064287695 cites W1997969441 @default.
- W2064287695 cites W2012305717 @default.
- W2064287695 cites W2013803723 @default.
- W2064287695 cites W2014059636 @default.
- W2064287695 cites W2017269547 @default.
- W2064287695 cites W2025327217 @default.
- W2064287695 cites W2038685994 @default.
- W2064287695 cites W2042580281 @default.
- W2064287695 cites W2043928972 @default.
- W2064287695 cites W2045172044 @default.
- W2064287695 cites W2045460009 @default.
- W2064287695 cites W2062313115 @default.
- W2064287695 cites W2064320035 @default.
- W2064287695 cites W2064792292 @default.
- W2064287695 cites W2071305684 @default.
- W2064287695 cites W2079986190 @default.
- W2064287695 cites W2080627425 @default.
- W2064287695 cites W2091241416 @default.
- W2064287695 cites W2097694282 @default.
- W2064287695 cites W2099664283 @default.
- W2064287695 cites W2102045006 @default.
- W2064287695 cites W2114324300 @default.
- W2064287695 cites W2115286737 @default.
- W2064287695 cites W2123030744 @default.
- W2064287695 cites W2133115600 @default.
- W2064287695 cites W2133826007 @default.
- W2064287695 cites W2139406636 @default.
- W2064287695 cites W2140148748 @default.
- W2064287695 cites W2168183582 @default.
- W2064287695 cites W2170910669 @default.
- W2064287695 doi "https://doi.org/10.1016/j.bios.2014.10.056" @default.
- W2064287695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25461169" @default.
- W2064287695 hasPublicationYear "2015" @default.
- W2064287695 type Work @default.
- W2064287695 sameAs 2064287695 @default.
- W2064287695 citedByCount "51" @default.
- W2064287695 countsByYear W20642876952015 @default.
- W2064287695 countsByYear W20642876952016 @default.
- W2064287695 countsByYear W20642876952017 @default.
- W2064287695 countsByYear W20642876952018 @default.
- W2064287695 countsByYear W20642876952019 @default.
- W2064287695 countsByYear W20642876952020 @default.
- W2064287695 countsByYear W20642876952021 @default.
- W2064287695 countsByYear W20642876952022 @default.
- W2064287695 countsByYear W20642876952023 @default.
- W2064287695 crossrefType "journal-article" @default.
- W2064287695 hasAuthorship W2064287695A5000779585 @default.
- W2064287695 hasAuthorship W2064287695A5006779868 @default.
- W2064287695 hasAuthorship W2064287695A5025546371 @default.
- W2064287695 hasAuthorship W2064287695A5044867217 @default.
- W2064287695 hasAuthorship W2064287695A5065586922 @default.
- W2064287695 hasConcept C10390740 @default.
- W2064287695 hasConcept C126322002 @default.
- W2064287695 hasConcept C136229726 @default.
- W2064287695 hasConcept C142724271 @default.
- W2064287695 hasConcept C160756335 @default.
- W2064287695 hasConcept C171250308 @default.
- W2064287695 hasConcept C185592680 @default.
- W2064287695 hasConcept C192562407 @default.
- W2064287695 hasConcept C2781362458 @default.
- W2064287695 hasConcept C30080830 @default.
- W2064287695 hasConcept C43617362 @default.
- W2064287695 hasConcept C500558357 @default.
- W2064287695 hasConcept C51915194 @default.
- W2064287695 hasConcept C71924100 @default.
- W2064287695 hasConcept C89560881 @default.
- W2064287695 hasConceptScore W2064287695C10390740 @default.
- W2064287695 hasConceptScore W2064287695C126322002 @default.
- W2064287695 hasConceptScore W2064287695C136229726 @default.
- W2064287695 hasConceptScore W2064287695C142724271 @default.
- W2064287695 hasConceptScore W2064287695C160756335 @default.
- W2064287695 hasConceptScore W2064287695C171250308 @default.
- W2064287695 hasConceptScore W2064287695C185592680 @default.
- W2064287695 hasConceptScore W2064287695C192562407 @default.
- W2064287695 hasConceptScore W2064287695C2781362458 @default.
- W2064287695 hasConceptScore W2064287695C30080830 @default.
- W2064287695 hasConceptScore W2064287695C43617362 @default.
- W2064287695 hasConceptScore W2064287695C500558357 @default.
- W2064287695 hasConceptScore W2064287695C51915194 @default.
- W2064287695 hasConceptScore W2064287695C71924100 @default.
- W2064287695 hasConceptScore W2064287695C89560881 @default.
- W2064287695 hasLocation W20642876951 @default.
- W2064287695 hasLocation W20642876952 @default.