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• W2064288167 abstract "Objective. This study aimed to investigate changes in urodynamic findings and symptoms after detrusor injections of botulinum toxin A (BTX-A) in children with idiopathic detrusor overactivity (IDO) and urge incontinence. Material and methods. Eight girls and five boys, aged 7–19 years, who had urge incontinence refractory to scheduled voiding and anticholinergics, were included this prospective study. Urodynamic studies showed postoperative IDO in 12 patients. A dose of 50–100 IU (1.3–4.8 IU/kg) BTX-A was primarily administered at 15–20 detrusor sites. A control urodynamic study was performed within 3 months after the injections. Seven patients had a repeated procedure 16 (range 6–24) months on the average after the first one. Results. Eleven of the 13 patients had daily incontinence and two had incontinence a couple of times a week in association with urge symptoms. Postoperatively, no patient had urinary retention, but one girl had a urinary tract infection 4 months after the therapy. Five patients had a full response, seven partial responses and one no response 1–3 months after the first treatment. After 1 year, three of nine patients still have full response. Maximum cystometric capacity increased after the first treatment from a median of 227 ml to 379 ml (p = 0.005) and the number of patients with uninhibited detrusor contractions more than 30 cmH2O during the filling phase decreased from eight to two out of 13 (p = 0.041). Conclusions. Intradetrusor BTX-A injections effectively reduce day-time wetting, significantly increase bladder volume and decrease detrusor overactivity in children with urge incontinence refractory to scheduled voidings and anticholinergics." @default.
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• W2064288167 date "2011-07-08" @default.
• W2064288167 modified "2023-10-05" @default.
• W2064288167 title "Urodynamic assessment of children treated with botulinum toxin A injections for urge incontinence: a pilot study" @default.
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• W2064288167 doi "https://doi.org/10.3109/00365599.2011.590997" @default.
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