FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064289597> ?p ?o ?g. }

• W2064289597 endingPage "584" @default.
• W2064289597 startingPage "578" @default.
• W2064289597 abstract "cAMP=: cyclic adenosine monophosphate; ER=: endoplasmic reticulum; GABA=: γ-aminobutyric acid; GAT=: γ-aminobutyric acid transporters; PKA=: protein kinase A; RT=: reticular thalamic; SCLC=: small-cell lung cancer; TC=: thalamocortical.γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the CNS and has a key role in modulating neuronal activity. GABA mediates its action via 2 classes of receptors, ionotropic GABAA and GABAC and metabotropic GABAB receptors. Unlike GABAA and C receptors, which form chloride channels and are involved in fast synaptic inhibition, GABAB receptors are guanine nucleotide-binding (G) protein-coupled receptors that modulate calcium (Ca2+) and potassium (K+) channels and elicit both presynaptic and slow postsynaptic inhibition. GABAB receptors are broadly expressed in the nervous system, modulating synaptic excitability and plasticity in the cerebral cortex, generating rhythmic activity in cortical and thalamic circuits, relaying primary afferent input to the spinal cord and brainstem, and affecting the activity of dopaminergic and other monoaminergic neurons. These receptors have been implicated in a wide variety of neurologic and psychiatric disorders, including absence seizures, γ-hydroxybutyrate toxicity, and, more recently, autoimmune limbic encephalitis. Baclofen is the only clinically available GABAB receptor agonist and is utilized for treatment of spasticity, dystonia, and some types of neuropathic pain. GABAB receptors may also provide a target for management of drug addiction, anxiety, and visceral pain. The structure, functions, and clinical implications of GABAB receptors have been extensively reviewed1,–,7### Subunit composition.GABAB receptors, like other G protein–coupled receptors, have a central core domain, constituted of 7 transmembrane helices, that is responsible for G-protein coupling. These receptors are members of class C G protein–coupled receptors, which also includes the metabotropic glutamate receptors, the calcium sensing receptor, and some taste receptors. The GABAB receptor, like other members of this class, is an obligatory heterodimer in vivo and is formed by 2 subunits, GABAB1 and GABAB23,8 (figure 1). The GABAB1 …" @default.
• W2064289597 created "2016-06-24" @default.
• W2064289597 creator A5069111019 @default.
• W2064289597 date "2012-02-20" @default.
• W2064289597 modified "2023-10-05" @default.
• W2064289597 title "GABAB receptors: Structure, functions, and clinical implications" @default.
• W2064289597 cites W1528907471 @default.
• W2064289597 cites W1548679143 @default.
• W2064289597 cites W1558288713 @default.
• W2064289597 cites W1607380607 @default.
• W2064289597 cites W190392689 @default.
• W2064289597 cites W1965432565 @default.
• W2064289597 cites W1979211041 @default.
• W2064289597 cites W1980316562 @default.
• W2064289597 cites W1981349335 @default.
• W2064289597 cites W1993532580 @default.
• W2064289597 cites W2004937932 @default.
• W2064289597 cites W2005982298 @default.
• W2064289597 cites W2009202604 @default.
• W2064289597 cites W2012534285 @default.
• W2064289597 cites W2017120126 @default.
• W2064289597 cites W2018313434 @default.
• W2064289597 cites W2022775848 @default.
• W2064289597 cites W2032733509 @default.
• W2064289597 cites W2034466321 @default.
• W2064289597 cites W2035447387 @default.
• W2064289597 cites W2036895793 @default.
• W2064289597 cites W2037618899 @default.
• W2064289597 cites W2039633685 @default.
• W2064289597 cites W2052007351 @default.
• W2064289597 cites W2065515889 @default.
• W2064289597 cites W2069219028 @default.
• W2064289597 cites W2070536774 @default.
• W2064289597 cites W2074909904 @default.
• W2064289597 cites W2077407052 @default.
• W2064289597 cites W2080760355 @default.
• W2064289597 cites W2087407051 @default.
• W2064289597 cites W2094381755 @default.
• W2064289597 cites W2094771978 @default.
• W2064289597 cites W2121584771 @default.
• W2064289597 cites W2123159874 @default.
• W2064289597 cites W2124517960 @default.
• W2064289597 cites W2127043216 @default.
• W2064289597 cites W2134960418 @default.
• W2064289597 cites W2150497419 @default.
• W2064289597 cites W2151872157 @default.
• W2064289597 cites W2157017305 @default.
• W2064289597 cites W2157230965 @default.
• W2064289597 cites W2157848053 @default.
• W2064289597 cites W2170177649 @default.
• W2064289597 cites W2416633679 @default.
• W2064289597 doi "https://doi.org/10.1212/wnl.0b013e318247cd03" @default.
• W2064289597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22351795" @default.
• W2064289597 hasPublicationYear "2012" @default.
• W2064289597 type Work @default.
• W2064289597 sameAs 2064289597 @default.
• W2064289597 citedByCount "123" @default.
• W2064289597 countsByYear W20642895972012 @default.
• W2064289597 countsByYear W20642895972013 @default.
• W2064289597 countsByYear W20642895972014 @default.
• W2064289597 countsByYear W20642895972015 @default.
• W2064289597 countsByYear W20642895972016 @default.
• W2064289597 countsByYear W20642895972017 @default.
• W2064289597 countsByYear W20642895972018 @default.
• W2064289597 countsByYear W20642895972019 @default.
• W2064289597 countsByYear W20642895972020 @default.
• W2064289597 countsByYear W20642895972021 @default.
• W2064289597 countsByYear W20642895972022 @default.
• W2064289597 countsByYear W20642895972023 @default.
• W2064289597 crossrefType "journal-article" @default.
• W2064289597 hasAuthorship W2064289597A5069111019 @default.
• W2064289597 hasConcept C101027131 @default.
• W2064289597 hasConcept C126322002 @default.
• W2064289597 hasConcept C15744967 @default.
• W2064289597 hasConcept C168258287 @default.
• W2064289597 hasConcept C169760540 @default.
• W2064289597 hasConcept C170493617 @default.
• W2064289597 hasConcept C71924100 @default.
• W2064289597 hasConceptScore W2064289597C101027131 @default.
• W2064289597 hasConceptScore W2064289597C126322002 @default.
• W2064289597 hasConceptScore W2064289597C15744967 @default.
• W2064289597 hasConceptScore W2064289597C168258287 @default.
• W2064289597 hasConceptScore W2064289597C169760540 @default.
• W2064289597 hasConceptScore W2064289597C170493617 @default.
• W2064289597 hasConceptScore W2064289597C71924100 @default.
• W2064289597 hasIssue "8" @default.
• W2064289597 hasLocation W20642895971 @default.
• W2064289597 hasLocation W20642895972 @default.
• W2064289597 hasOpenAccess W2064289597 @default.
• W2064289597 hasPrimaryLocation W20642895971 @default.
• W2064289597 hasRelatedWork W1654156243 @default.
• W2064289597 hasRelatedWork W1982923724 @default.
• W2064289597 hasRelatedWork W2027622554 @default.
• W2064289597 hasRelatedWork W2029785909 @default.
• W2064289597 hasRelatedWork W2047960587 @default.
• W2064289597 hasRelatedWork W2085235923 @default.
• W2064289597 hasRelatedWork W2120131984 @default.
• W2064289597 hasRelatedWork W2402694965 @default.

• next