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• W2064291068 abstract "Tau is a microtubule-associated protein involved in axonal elongation and central to the pathogenesis of a number of neurodegenerative conditions. To better establish the contribution of the cellular context to tau-dependent microtubule organization, we compared the phenotypes resulting from heterologous tau expression in different mammalian cell lines after disruption of the actin cytoskeleton. After cytochalasin D treatment, tau-expressing CHO cells display one or two long neurite-like extensions whereas cells transfected with MAP2c developed multiple shorter processes. By contrast, under the same conditions, tau-transfected PtK2 cells elaborate microtubule bundles forming numerous processes. These results suggest that cell-specific factors are involved in tau-dependent microtubule organization, a notion that could facilitate functional assessment of tau abnormalities associated with neurodegenerative disease." @default.
• W2064291068 created "2016-06-24" @default.
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• W2064291068 date "2004-10-01" @default.
• W2064291068 modified "2023-09-27" @default.
• W2064291068 title "Distinct patterns of tau-dependent process formation in mammalian cell lines" @default.
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• W2064291068 doi "https://doi.org/10.1097/00001756-200410050-00016" @default.
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