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- W2064297124 abstract "Dominant temperature-sensitive lethal and semilethal (DTS-L) mutations induced by ethyl methanesulfonate have been recovered in chromosome 2 of Drosophila melanogaster. The 19 (0.39% of the chromosomes screened) characterized had greater than 65 per cent viability at 22 degrees +/- 2 degrees C and less than 5 per cent at 29 degrees +/- 0.5 degrees C. Fifteen of the DTS-L's map genetically as point mutants, one appears to be a synthetic lethal, and the remaining three yielded sterile females. Ten different DTS mutants had a high survival in triploid females at 29 degrees C. Eleven DTS-L's were found to map in the same genetic region (dp-b). All behaved as recessive lethals at 22 degrees C and failed to survive at 22 degrees C when combined with mutants 3 and 12. Crosses of the 11 mutants in all possible pairwise combinations yielded a circular complementation map with a side branch. The effective lethal phases and temperature-sensitive periods during development were determined for 15 of the mutants." @default.
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- W2064297124 date "1969-02-01" @default.
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- W2064297124 title "TEMPERATURE-SENSITIVE MUTATIONS IN <i>Drosophila melanogaster</i> , III. DOMINANT LETHALS AND SEMILETHALS ON CHROMOSOME 2" @default.
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- W2064297124 doi "https://doi.org/10.1073/pnas.62.2.369" @default.
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