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- W2064309780 abstract "Many bacteria use chemical signals to coordinate group behaviour. A signal that suppresses virulence has been identified in the bacterium that causes cholera, and could be a new therapeutic target. In a process called quorum sensing, certain bacteria can communicate with each other using chemical signalling molecules, allowing them to synchronize gene expression so that they act virtually as multicellular organisms. The cholera pathogen Vibrio cholerae uses quorum sensing to control virulence and to organize the biofilms that contribute to the difficulties of treating the infection. Now the major V. cholerae quorum-sensing signalling molecule, an autoinducer called CAI-1, has been identified and characterized as (S)-3-hydroxytridecan-4-one, a molecule new to biology. Providing CAI-1 to the bacterium terminates the production of factors required for pathogenicity, suggesting a possible new treatment for this major pathogen." @default.
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- W2064309780 date "2007-12-01" @default.
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- W2064309780 title "Bilingual bacteria" @default.
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- W2064309780 doi "https://doi.org/10.1038/450805a" @default.
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