FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064311146> ?p ?o ?g. }

• W2064311146 endingPage "346" @default.
• W2064311146 startingPage "339" @default.
• W2064311146 abstract "Summary Radiation‐induced brain disorders (RIBD) are uncommon and they are grave sequelae of conventional radiotherapy. In the present report, we describe the clinical spectrum of RIBD in 11 patients who received post‐surgery conventional megavoltage irradiation for residual pituitary tumours. Of these 11 patients (nine men, two women), seven had been treated for non‐functioning pituitary tumours and four for somatotropinomas. At the time of irradiation the age of these patients ranged from 30 to 59 years (mean, 39.4 ± 8.3; median, 36) with a follow‐up period of 6−96 months (mean, 18.3 ± 26.4; median, 11). The dose of radiation ranged from 45 to 90 Gy (mean, 51.3 ± 13.4; median, 45), which was given in 15−30 fractions (mean, 18.6 ± 5.0; median, 15) with 2.8 ± 0.3 Gy (median, 3) per fraction. The biological effective dose calculated for late complications in these patients ranged from 78.7 to 180 Gy (mean, 99.1 ± 27.5; median, 90). The lag time between tumour irradiation and the onset of symptoms ranged from 6 to 168 months (mean, 46.3 ± 57.0; median, 57). The clinical spectrum of RIBD included new‐onset visual abnormalities in five, cerebral radionecrosis in the form of altered sensorium in four, generalized seizures in four, cognitive dysfunction in five, dementia in three and motor deficits in two patients. Magnetic resonance imaging (MRI)/CT of the brain was suggestive of radionecrosis in eight, cerebral oedema in three, cerebral atrophy in two and second neoplasia in one patient. Associated hormone deficiencies at presentation were hypogonadism in eight, hypoadrenalism in six, hypothyroidism in four and diabetes insipidus in one patient. Autopsy in two patients showed primitive neuroectodermal tumour (PNET) and brainstem radionecrosis in one, and a cystic lesion in the left frontal lobe following radionecrosis in the other. We conclude that RIBD have distinctive but varying clinical and radiological presentations. Diabetes insipidus and PNET as a second neoplastic disorder in adults following pituitary irradiation have not been reported previously." @default.
• W2064311146 created "2016-06-24" @default.
• W2064311146 creator A5013334398 @default.
• W2064311146 creator A5020805750 @default.
• W2064311146 creator A5025243355 @default.
• W2064311146 creator A5035391622 @default.
• W2064311146 creator A5039160908 @default.
• W2064311146 creator A5056473077 @default.
• W2064311146 creator A5060183060 @default.
• W2064311146 date "2004-09-01" @default.
• W2064311146 modified "2023-10-10" @default.
• W2064311146 title "Radiation-induced brain disorders in patients with pituitary tumours" @default.
• W2064311146 cites W1973059597 @default.
• W2064311146 cites W1974228588 @default.
• W2064311146 cites W1976552389 @default.
• W2064311146 cites W1992170951 @default.
• W2064311146 cites W1995656165 @default.
• W2064311146 cites W2006745985 @default.
• W2064311146 cites W2009148926 @default.
• W2064311146 cites W2013860854 @default.
• W2064311146 cites W2020217917 @default.
• W2064311146 cites W2023676599 @default.
• W2064311146 cites W2027814107 @default.
• W2064311146 cites W2033031050 @default.
• W2064311146 cites W2045287329 @default.
• W2064311146 cites W2049215489 @default.
• W2064311146 cites W2057537176 @default.
• W2064311146 cites W2060487392 @default.
• W2064311146 cites W2075181027 @default.
• W2064311146 cites W2078305681 @default.
• W2064311146 cites W2089885944 @default.
• W2064311146 cites W2109422467 @default.
• W2064311146 cites W2127180535 @default.
• W2064311146 cites W2150366290 @default.
• W2064311146 cites W2162531066 @default.
• W2064311146 cites W2262546632 @default.
• W2064311146 doi "https://doi.org/10.1111/j.0004-8461.2003.01237.x" @default.
• W2064311146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15344984" @default.
• W2064311146 hasPublicationYear "2004" @default.
• W2064311146 type Work @default.
• W2064311146 sameAs 2064311146 @default.
• W2064311146 citedByCount "33" @default.
• W2064311146 countsByYear W20643111462013 @default.
• W2064311146 countsByYear W20643111462014 @default.
• W2064311146 countsByYear W20643111462015 @default.
• W2064311146 countsByYear W20643111462016 @default.
• W2064311146 countsByYear W20643111462017 @default.
• W2064311146 countsByYear W20643111462019 @default.
• W2064311146 countsByYear W20643111462020 @default.
• W2064311146 countsByYear W20643111462021 @default.
• W2064311146 countsByYear W20643111462022 @default.
• W2064311146 countsByYear W20643111462023 @default.
• W2064311146 crossrefType "journal-article" @default.
• W2064311146 hasAuthorship W2064311146A5013334398 @default.
• W2064311146 hasAuthorship W2064311146A5020805750 @default.
• W2064311146 hasAuthorship W2064311146A5025243355 @default.
• W2064311146 hasAuthorship W2064311146A5035391622 @default.
• W2064311146 hasAuthorship W2064311146A5039160908 @default.
• W2064311146 hasAuthorship W2064311146A5056473077 @default.
• W2064311146 hasAuthorship W2064311146A5060183060 @default.
• W2064311146 hasConcept C126322002 @default.
• W2064311146 hasConcept C126838900 @default.
• W2064311146 hasConcept C143409427 @default.
• W2064311146 hasConcept C2779717322 @default.
• W2064311146 hasConcept C2781172350 @default.
• W2064311146 hasConcept C2989005 @default.
• W2064311146 hasConcept C509974204 @default.
• W2064311146 hasConcept C71924100 @default.
• W2064311146 hasConceptScore W2064311146C126322002 @default.
• W2064311146 hasConceptScore W2064311146C126838900 @default.
• W2064311146 hasConceptScore W2064311146C143409427 @default.
• W2064311146 hasConceptScore W2064311146C2779717322 @default.
• W2064311146 hasConceptScore W2064311146C2781172350 @default.
• W2064311146 hasConceptScore W2064311146C2989005 @default.
• W2064311146 hasConceptScore W2064311146C509974204 @default.
• W2064311146 hasConceptScore W2064311146C71924100 @default.
• W2064311146 hasIssue "3" @default.
• W2064311146 hasLocation W20643111461 @default.
• W2064311146 hasLocation W20643111462 @default.
• W2064311146 hasOpenAccess W2064311146 @default.
• W2064311146 hasPrimaryLocation W20643111461 @default.
• W2064311146 hasRelatedWork W1558127559 @default.
• W2064311146 hasRelatedWork W1570930502 @default.
• W2064311146 hasRelatedWork W1997829388 @default.
• W2064311146 hasRelatedWork W2000936098 @default.
• W2064311146 hasRelatedWork W2017803018 @default.
• W2064311146 hasRelatedWork W2061907775 @default.
• W2064311146 hasRelatedWork W2156691834 @default.
• W2064311146 hasRelatedWork W2348929847 @default.
• W2064311146 hasRelatedWork W2359577892 @default.
• W2064311146 hasRelatedWork W2392600402 @default.
• W2064311146 hasVolume "48" @default.
• W2064311146 isParatext "false" @default.
• W2064311146 isRetracted "false" @default.
• W2064311146 magId "2064311146" @default.
• W2064311146 workType "article" @default.