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- W2064327627 abstract "Abstract The aim of this study was to investigate the in vitro and in vivo performance of salbutamol sulfate press-coated tablets for delayed release. The in vitro release behavior of press-coated tablets with the outer layer of PEG 6000/ Eudragit S100 blends (2:1) in pH 1.2 (0.1 mol L -1 HCl) and then pH 6.8 buffer solution was examined. Morphological change of the press-coated tablet during in vitro release was recorded with a digital camera. Release of salbutamol sulfate from press-coated tablets was less than 5 % before 3 h and was completed after 8 h in pH 6.8 phosphate buffer solution. In vivo gamma scintigraphy study carried out on healthy men indicated that the designed system released the drug in lower parts of the GI tract after a lag time of 5 hours. The results showed the capability of the system of achieving delayed release of the drug in both in vitro and in vivo gamma scintigraphy studies." @default.
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- W2064327627 date "2013-12-01" @default.
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- W2064327627 title "In vitro dissolution and in vivo gamma scintigraphic evaluation of press-coated salbutamol sulfate tablets" @default.
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- W2064327627 doi "https://doi.org/10.2478/acph-2013-0035" @default.
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