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• W2064349006 abstract "To determine if particle shape can be engineered to inhibit phagocytosis of drug delivery particles by macrophages, which can be a significant barrier to successful therapeutic delivery. Non-spherical polystyrene particles were fabricated by stretching spherical particles embedded in a polymer film. A rat alveolar macrophage cell line was used as model macrophages. Phagocytosis of particles was assessed using time-lapse video microscopy and fluorescence microscopy. We fabricated worm-like particles with very high aspect ratios (>20). This shape exhibits negligible phagocytosis compared to conventional spherical particles of equal volume. Reduced phagocytosis is a result of decreasing high curvature regions of the particle to two single points, the ends of the worm-like particles. Internalization is possible only at these points, while attachment anywhere along the length of the particles inhibits internalization due to the low curvature. Shape-induced inhibition of phagocytosis of drug delivery particles is possible by minimizing the size-normalized curvature of particles. We have created a high aspect ratio shape that exhibits negligible uptake by macrophages." @default.
• W2064349006 created "2016-06-24" @default.
• W2064349006 creator A5005311108 @default.
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• W2064349006 date "2008-06-12" @default.
• W2064349006 modified "2023-10-16" @default.
• W2064349006 title "Shape Induced Inhibition of Phagocytosis of Polymer Particles" @default.
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• W2064349006 doi "https://doi.org/10.1007/s11095-008-9626-z" @default.
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