Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064353854> ?p ?o ?g. }
- W2064353854 endingPage "1106" @default.
- W2064353854 startingPage "1097" @default.
- W2064353854 abstract "This study aimed to determine whether epidermal growth factor receptor (EGFR), which has been reported to be frequently overexpressed in esophageal carcinoma cells, is actually activated in the cells. Paraffin‐embedded specimens of 39 cases of esophageal carcinoma were analyzed immunohistochemically with anti‐EGFR polyclonal antibody (α‐EGFR Ab) and also an anti‐phospho‐EGFR‐specific polyclonal antibody (α‐p‐EGFR Tyr992 Ab) that specifically recognizes phosphorylated tyrosine 992 of EGFR. All of the 39 cases were found to express EGFR, but the expression levels were not significantly higher than those in basal cells of the normal esophageal epithelium. In 38 of the 39 cases, α‐p‐EGFR Tyr992 immunoreactivity was evident. Interestingly, the positively stained carcinoma cells were not distributed diffusely, and strongly immunostained cells tended to be localized in areas of severe dysplasia and in microinvasive foci just adjacent to the main invasive carcinoma. However, the deeply invasive front never exhibited positive immunoreactivity. The present findings suggest that phosphorylation of EGFR Tyr992 may play some specific functional role in esophageal carcinomas besides promotion of cell proliferation." @default.
- W2064353854 created "2016-06-24" @default.
- W2064353854 creator A5029313706 @default.
- W2064353854 creator A5030442949 @default.
- W2064353854 creator A5033485126 @default.
- W2064353854 creator A5040303732 @default.
- W2064353854 creator A5061914823 @default.
- W2064353854 creator A5090297788 @default.
- W2064353854 date "2008-12-01" @default.
- W2064353854 modified "2023-10-16" @default.
- W2064353854 title "Enhanced phosphorylation of the epidermal growth factor receptor at the site of tyrosine 992 in esophageal carcinomas" @default.
- W2064353854 cites W1483470782 @default.
- W2064353854 cites W1518877053 @default.
- W2064353854 cites W1720535299 @default.
- W2064353854 cites W1963853174 @default.
- W2064353854 cites W1974024530 @default.
- W2064353854 cites W1979040485 @default.
- W2064353854 cites W1987276632 @default.
- W2064353854 cites W1988557714 @default.
- W2064353854 cites W2004394004 @default.
- W2064353854 cites W2010640454 @default.
- W2064353854 cites W2023575200 @default.
- W2064353854 cites W2032955821 @default.
- W2064353854 cites W2061119693 @default.
- W2064353854 cites W2063867686 @default.
- W2064353854 cites W2093226717 @default.
- W2064353854 cites W2093770224 @default.
- W2064353854 cites W2095342969 @default.
- W2064353854 cites W2106000067 @default.
- W2064353854 cites W2118375252 @default.
- W2064353854 cites W2134709564 @default.
- W2064353854 cites W2158731289 @default.
- W2064353854 cites W2159820833 @default.
- W2064353854 cites W2164682544 @default.
- W2064353854 cites W2171467310 @default.
- W2064353854 cites W2411095871 @default.
- W2064353854 cites W51995314 @default.
- W2064353854 doi "https://doi.org/10.1111/j.1600-0463.2008.01125.x" @default.
- W2064353854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19133013" @default.
- W2064353854 hasPublicationYear "2008" @default.
- W2064353854 type Work @default.
- W2064353854 sameAs 2064353854 @default.
- W2064353854 citedByCount "8" @default.
- W2064353854 countsByYear W20643538542012 @default.
- W2064353854 countsByYear W20643538542013 @default.
- W2064353854 countsByYear W20643538542016 @default.
- W2064353854 crossrefType "journal-article" @default.
- W2064353854 hasAuthorship W2064353854A5029313706 @default.
- W2064353854 hasAuthorship W2064353854A5030442949 @default.
- W2064353854 hasAuthorship W2064353854A5033485126 @default.
- W2064353854 hasAuthorship W2064353854A5040303732 @default.
- W2064353854 hasAuthorship W2064353854A5061914823 @default.
- W2064353854 hasAuthorship W2064353854A5090297788 @default.
- W2064353854 hasConcept C11960822 @default.
- W2064353854 hasConcept C126322002 @default.
- W2064353854 hasConcept C142724271 @default.
- W2064353854 hasConcept C159654299 @default.
- W2064353854 hasConcept C170493617 @default.
- W2064353854 hasConcept C203014093 @default.
- W2064353854 hasConcept C204232928 @default.
- W2064353854 hasConcept C2776362946 @default.
- W2064353854 hasConcept C2777546739 @default.
- W2064353854 hasConcept C2777553839 @default.
- W2064353854 hasConcept C2779438470 @default.
- W2064353854 hasConcept C502942594 @default.
- W2064353854 hasConcept C71924100 @default.
- W2064353854 hasConcept C86803240 @default.
- W2064353854 hasConcept C95444343 @default.
- W2064353854 hasConcept C956191 @default.
- W2064353854 hasConceptScore W2064353854C11960822 @default.
- W2064353854 hasConceptScore W2064353854C126322002 @default.
- W2064353854 hasConceptScore W2064353854C142724271 @default.
- W2064353854 hasConceptScore W2064353854C159654299 @default.
- W2064353854 hasConceptScore W2064353854C170493617 @default.
- W2064353854 hasConceptScore W2064353854C203014093 @default.
- W2064353854 hasConceptScore W2064353854C204232928 @default.
- W2064353854 hasConceptScore W2064353854C2776362946 @default.
- W2064353854 hasConceptScore W2064353854C2777546739 @default.
- W2064353854 hasConceptScore W2064353854C2777553839 @default.
- W2064353854 hasConceptScore W2064353854C2779438470 @default.
- W2064353854 hasConceptScore W2064353854C502942594 @default.
- W2064353854 hasConceptScore W2064353854C71924100 @default.
- W2064353854 hasConceptScore W2064353854C86803240 @default.
- W2064353854 hasConceptScore W2064353854C95444343 @default.
- W2064353854 hasConceptScore W2064353854C956191 @default.
- W2064353854 hasIssue "12" @default.
- W2064353854 hasLocation W20643538541 @default.
- W2064353854 hasLocation W20643538542 @default.
- W2064353854 hasOpenAccess W2064353854 @default.
- W2064353854 hasPrimaryLocation W20643538541 @default.
- W2064353854 hasRelatedWork W1576402354 @default.
- W2064353854 hasRelatedWork W184476204 @default.
- W2064353854 hasRelatedWork W1898795080 @default.
- W2064353854 hasRelatedWork W1985211644 @default.
- W2064353854 hasRelatedWork W1988749775 @default.
- W2064353854 hasRelatedWork W2022006194 @default.
- W2064353854 hasRelatedWork W2072299589 @default.
- W2064353854 hasRelatedWork W2087695146 @default.