Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064364073> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2064364073 endingPage "2352" @default.
- W2064364073 startingPage "2346" @default.
- W2064364073 abstract "By genetic engineering of human CR1 cDNA and its stable transfection into cells we have produced a cell line which expresses CR1 anchored to the cell surface by a glycolipid anchor. The glycosyl-phosphatidylinositol (GPI)-CR1 protects cells intrinsically from damage mediated by complement activated through the classical pathway. Cell surface GPI-CR1 is more efficient on a molar basis than soluble CR1 in the assay, but extrinsic protection of other cells was not obtained. Soluble CR1-protected cells extrinsically in the assay but was required at nearly ten fold higher amounts than the intrinsic protection conferred by GPI-anchored CR1. Additionally, GPI-CR1 was shown to act as a co-factor to Factor I in the generation of C3c from iC3b. Since GPI-anchored proteins can incorporate spontaneously into the membranes of living cells by virtue of their lipid tails, the isolated GPI-CR1 will be used to introduce CR1 on to the surfaces of many different types of cell so that its role in immunity can be further investigated." @default.
- W2064364073 created "2016-06-24" @default.
- W2064364073 creator A5009118705 @default.
- W2064364073 creator A5015981919 @default.
- W2064364073 creator A5079987537 @default.
- W2064364073 date "1993-09-01" @default.
- W2064364073 modified "2023-09-27" @default.
- W2064364073 title "Construction, expression and functional analysis of a glycolipid-linked form of CR1" @default.
- W2064364073 cites W1587809300 @default.
- W2064364073 cites W1604210437 @default.
- W2064364073 cites W1811603389 @default.
- W2064364073 cites W1966286149 @default.
- W2064364073 cites W2005482754 @default.
- W2064364073 cites W2011216554 @default.
- W2064364073 cites W2020469064 @default.
- W2064364073 cites W2023235169 @default.
- W2064364073 cites W2052571219 @default.
- W2064364073 cites W2055785572 @default.
- W2064364073 cites W2059544533 @default.
- W2064364073 cites W2062147146 @default.
- W2064364073 cites W2063431146 @default.
- W2064364073 cites W2068418997 @default.
- W2064364073 cites W2071177681 @default.
- W2064364073 cites W2073755366 @default.
- W2064364073 cites W2083180621 @default.
- W2064364073 cites W2099349184 @default.
- W2064364073 cites W2100837269 @default.
- W2064364073 cites W2152020672 @default.
- W2064364073 cites W2401878947 @default.
- W2064364073 doi "https://doi.org/10.1002/eji.1830230944" @default.
- W2064364073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8370411" @default.
- W2064364073 hasPublicationYear "1993" @default.
- W2064364073 type Work @default.
- W2064364073 sameAs 2064364073 @default.
- W2064364073 citedByCount "9" @default.
- W2064364073 crossrefType "journal-article" @default.
- W2064364073 hasAuthorship W2064364073A5009118705 @default.
- W2064364073 hasAuthorship W2064364073A5015981919 @default.
- W2064364073 hasAuthorship W2064364073A5079987537 @default.
- W2064364073 hasConcept C111684460 @default.
- W2064364073 hasConcept C1491633281 @default.
- W2064364073 hasConcept C153911025 @default.
- W2064364073 hasConcept C159654299 @default.
- W2064364073 hasConcept C191590540 @default.
- W2064364073 hasConcept C203014093 @default.
- W2064364073 hasConcept C22222904 @default.
- W2064364073 hasConcept C54009773 @default.
- W2064364073 hasConcept C54355233 @default.
- W2064364073 hasConcept C55493867 @default.
- W2064364073 hasConcept C81885089 @default.
- W2064364073 hasConcept C86803240 @default.
- W2064364073 hasConcept C95444343 @default.
- W2064364073 hasConceptScore W2064364073C111684460 @default.
- W2064364073 hasConceptScore W2064364073C1491633281 @default.
- W2064364073 hasConceptScore W2064364073C153911025 @default.
- W2064364073 hasConceptScore W2064364073C159654299 @default.
- W2064364073 hasConceptScore W2064364073C191590540 @default.
- W2064364073 hasConceptScore W2064364073C203014093 @default.
- W2064364073 hasConceptScore W2064364073C22222904 @default.
- W2064364073 hasConceptScore W2064364073C54009773 @default.
- W2064364073 hasConceptScore W2064364073C54355233 @default.
- W2064364073 hasConceptScore W2064364073C55493867 @default.
- W2064364073 hasConceptScore W2064364073C81885089 @default.
- W2064364073 hasConceptScore W2064364073C86803240 @default.
- W2064364073 hasConceptScore W2064364073C95444343 @default.
- W2064364073 hasIssue "9" @default.
- W2064364073 hasLocation W20643640731 @default.
- W2064364073 hasLocation W20643640732 @default.
- W2064364073 hasOpenAccess W2064364073 @default.
- W2064364073 hasPrimaryLocation W20643640731 @default.
- W2064364073 hasRelatedWork W2040998738 @default.
- W2064364073 hasRelatedWork W2053393868 @default.
- W2064364073 hasRelatedWork W2347120132 @default.
- W2064364073 hasRelatedWork W2348326337 @default.
- W2064364073 hasRelatedWork W2358953894 @default.
- W2064364073 hasRelatedWork W2379152510 @default.
- W2064364073 hasRelatedWork W2379416539 @default.
- W2064364073 hasRelatedWork W2384261171 @default.
- W2064364073 hasRelatedWork W2384429658 @default.
- W2064364073 hasRelatedWork W3032689747 @default.
- W2064364073 hasVolume "23" @default.
- W2064364073 isParatext "false" @default.
- W2064364073 isRetracted "false" @default.
- W2064364073 magId "2064364073" @default.
- W2064364073 workType "article" @default.