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- W2064408085 abstract "An efficient asymmetric synthesis of the 2-hydroxymethyl 3,6-disubstituted piperidine alkaloid, (−)-deoxoprosophylline, is described. The key step of this route is the SmI2-mediated cross-coupling of chiral N-tert-butanesulfinyl imine 9 with aldehyde 11 to construct hydroxymethyl-β-amino alcohol 12b in 83% yield and high diastereoselectivity (>99%, de)." @default.
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- W2064408085 date "2008-12-01" @default.
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- W2064408085 title "Concise asymmetric synthesis of (−)-deoxoprosophylline" @default.
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- W2064408085 doi "https://doi.org/10.1016/j.tetasy.2008.12.014" @default.
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