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• W2064409092 abstract "1. The incubation of rat myocardial sarcolemmal membranes with 10−4 M lidocaine or procainamide results in a decreased fluorescence polarization of the extrinsic probes (diphenylhexatriene and 12-anthroylstearate) and in the stimulation of the membrane-bound high affinity cyclic AMP phosphodiesterase activity (PDE). 2. Lidocaine or procainamide do not contrast, but facilitate the aminophylline inhibitory action on the PDE activity, without modifying the basic molecular mechanism of the inhibitory action. 3. The amplitudes of the effects described are inversely correlated to the temperature, being greater at the lower tested temperature (25° > 30° > 37°C)." @default.
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• W2064409092 date "1985-01-01" @default.
• W2064409092 modified "2023-09-25" @default.
• W2064409092 title "The effects of lidocaine and procainamide on the sarcolemmal membrane high affinity cyclic AMP phosphodiesterase of rat myocardium" @default.
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• W2064409092 doi "https://doi.org/10.1016/0306-3623(85)90046-1" @default.
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