FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064418897> ?p ?o ?g. }

• W2064418897 endingPage "62" @default.
• W2064418897 startingPage "52" @default.
• W2064418897 abstract "Recent studies have demonstrated neuroprotective effects of therapeutic hypercapnia for different forms of brain injury. However, few studies have assessed the neuroprotective and neurobehavioral effects of hypercapnia in focal cerebral ischemia, and the underlying mechanisms are still unclear. Here, we investigated the effects of therapeutic hypercapnia in focal cerebral ischemia in the rat middle cerebral artery occlusion/reperfusion (MCAO/R) model. Adult male Sprague Dawley rats were subjected to 90 min of MCAO/R and subsequently exposed to increased carbon dioxide (CO2) levels to maintain arterial blood CO2 tension (PaCO2) between 80 and 100 mmHg for 2 h. Neurological deficits were evaluated with the corner test at days 1, 7, 14, and 28. Infarction volume and apoptotic changes were assessed by 2, 3, 7-triphenyltetrazolium chloride (TTC) staining, and terminal deoxynucleotidyl transferase-mediated 2′-deoxyuridine 5′-triphosphate-biotin nick end labeling (TUNEL) staining at 24 h after reperfusion. Apoptosis-related proteins (Bcl-2, Bax, cytochrome c, and caspase-3) were investigated by western blotting. The results of this study showed that therapeutic hypercapnia significantly reduced infarct volume and improved neurological scores after MCAO/R. Moreover, hypercapnia treatment increased the survival rate at 28 days after reperfusion. The TUNEL-positive neurons in the ipsilateral cortex were significantly decreased in the hypercapnia group. Mitochondrial Bcl-2 and Bax cortical expression levels were significantly higher and lower, respectively, in hypercapnia-treated rats. In addition, hypercapnia treatment decreased cytosolic cytochrome c and cleaved caspase-3 expression and increased cytosolic Bax expression. These findings indicate that therapeutic hypercapnia preserves brain tissue and promotes functional neurological recovery through antiapoptotic mechanisms." @default.
• W2064418897 created "2016-06-24" @default.
• W2064418897 creator A5002586536 @default.
• W2064418897 creator A5006356792 @default.
• W2064418897 creator A5052342599 @default.
• W2064418897 creator A5070120253 @default.
• W2064418897 creator A5080888541 @default.
• W2064418897 creator A5091443349 @default.
• W2064418897 date "2013-10-01" @default.
• W2064418897 modified "2023-09-26" @default.
• W2064418897 title "Therapeutic hypercapnia improves functional recovery and attenuates injury via antiapoptotic mechanisms in a rat focal cerebral ischemia/reperfusion model" @default.
• W2064418897 cites W1580379217 @default.
• W2064418897 cites W1971839588 @default.
• W2064418897 cites W1972544011 @default.
• W2064418897 cites W1975701836 @default.
• W2064418897 cites W1982911235 @default.
• W2064418897 cites W1986228861 @default.
• W2064418897 cites W2005393880 @default.
• W2064418897 cites W2007713916 @default.
• W2064418897 cites W2010518906 @default.
• W2064418897 cites W2010656523 @default.
• W2064418897 cites W2013636050 @default.
• W2064418897 cites W2016773564 @default.
• W2064418897 cites W2019554063 @default.
• W2064418897 cites W2022219828 @default.
• W2064418897 cites W2026069542 @default.
• W2064418897 cites W2027916339 @default.
• W2064418897 cites W2031305788 @default.
• W2064418897 cites W2035335195 @default.
• W2064418897 cites W2035877136 @default.
• W2064418897 cites W2037905031 @default.
• W2064418897 cites W2039515131 @default.
• W2064418897 cites W2041471383 @default.
• W2064418897 cites W2043675475 @default.
• W2064418897 cites W2048734958 @default.
• W2064418897 cites W2051070266 @default.
• W2064418897 cites W2052092902 @default.
• W2064418897 cites W2053639892 @default.
• W2064418897 cites W2060208551 @default.
• W2064418897 cites W2062324073 @default.
• W2064418897 cites W2062809665 @default.
• W2064418897 cites W2080052951 @default.
• W2064418897 cites W2080552795 @default.
• W2064418897 cites W2092870266 @default.
• W2064418897 cites W2094406397 @default.
• W2064418897 cites W2103757659 @default.
• W2064418897 cites W2112505121 @default.
• W2064418897 cites W2116951446 @default.
• W2064418897 cites W2117253950 @default.
• W2064418897 cites W2118625836 @default.
• W2064418897 cites W2119683782 @default.
• W2064418897 cites W2136125708 @default.
• W2064418897 cites W2136781825 @default.
• W2064418897 cites W2139260688 @default.
• W2064418897 cites W2146591910 @default.
• W2064418897 cites W2147257512 @default.
• W2064418897 cites W2160959923 @default.
• W2064418897 cites W2162838438 @default.
• W2064418897 cites W2165824005 @default.
• W2064418897 cites W2166302161 @default.
• W2064418897 cites W2166615294 @default.
• W2064418897 cites W2928618355 @default.
• W2064418897 cites W4243843543 @default.
• W2064418897 doi "https://doi.org/10.1016/j.brainres.2013.08.014" @default.
• W2064418897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23939225" @default.
• W2064418897 hasPublicationYear "2013" @default.
• W2064418897 type Work @default.
• W2064418897 sameAs 2064418897 @default.
• W2064418897 citedByCount "37" @default.
• W2064418897 countsByYear W20644188972014 @default.
• W2064418897 countsByYear W20644188972015 @default.
• W2064418897 countsByYear W20644188972016 @default.
• W2064418897 countsByYear W20644188972017 @default.
• W2064418897 countsByYear W20644188972018 @default.
• W2064418897 countsByYear W20644188972019 @default.
• W2064418897 countsByYear W20644188972020 @default.
• W2064418897 countsByYear W20644188972021 @default.
• W2064418897 countsByYear W20644188972022 @default.
• W2064418897 countsByYear W20644188972023 @default.
• W2064418897 crossrefType "journal-article" @default.
• W2064418897 hasAuthorship W2064418897A5002586536 @default.
• W2064418897 hasAuthorship W2064418897A5006356792 @default.
• W2064418897 hasAuthorship W2064418897A5052342599 @default.
• W2064418897 hasAuthorship W2064418897A5070120253 @default.
• W2064418897 hasAuthorship W2064418897A5080888541 @default.
• W2064418897 hasAuthorship W2064418897A5091443349 @default.
• W2064418897 hasConcept C126322002 @default.
• W2064418897 hasConcept C142724271 @default.
• W2064418897 hasConcept C196795494 @default.
• W2064418897 hasConcept C204232928 @default.
• W2064418897 hasConcept C25498285 @default.
• W2064418897 hasConcept C2776151105 @default.
• W2064418897 hasConcept C2777037550 @default.
• W2064418897 hasConcept C2778553927 @default.
• W2064418897 hasConcept C2779740913 @default.
• W2064418897 hasConcept C2780114680 @default.
• W2064418897 hasConcept C2992339995 @default.
• W2064418897 hasConcept C42219234 @default.

• next