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- W2064423280 abstract "Abstract Effects of methylmercuric chloride (CH 3 HgCl) and mercuric chloride (HgCl 2 ) on electrical properties of muscle fibers and on neuromuscular transmission were studied in the isolated sciatic nerve-sartorius muscle preparation of the frog with an intracellular recording technique. HgCl 2 at 0.04 m m produced decreases in resting potential, effective resistance, and the amplitude of action potentials, and eventually led to electrical inexcitability. On the other hand, 0.04 m m CH 3 HgCl produced little effect on these electrical properties but at a concentration of 0.4 m m caused depolarization and inexcitability. Both compounds caused a large increase in the frequency of spontaneous transmitter release. The increase by CH 3 HgCl was associated with increase in the amplitude of mEPPs, whereas that by HgCl 2 was associated with a decrease, the latter being due to decreases in resting potential and effective resistance. Both compounds also caused a transient increase in evoked transmitter release. Eventually, either spontaneous or evoked transmitter release was similarly suppressed after long-term exposure. It may be concluded that the primary action of CH 3 HgCl is on the presynaptic site, whereas that of HgCl 2 is both on the pre-and postsynaptic sites." @default.
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- W2064423280 date "1976-08-01" @default.
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- W2064423280 title "An electrophysiological study of the action of methylmercuric chloride and mercuric chloride on the sciatic nerve-sartorius muscle preparation of the frog" @default.
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- W2064423280 doi "https://doi.org/10.1016/0041-008x(76)90097-1" @default.
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