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• W2064430449 abstract "Steady-state levels of gp140proto-trk in cell lines and tumor tissues of neuroblastoma were examined by immunoblotting with anti-gp140proto-trk. The level of gp140proto-trk varied but showed good correlations with the stage of the tumor and the age of the patients at the time of diagnosis. Moreover, patients with higher expression of gp140proto-trk clearly had a far better survival rate than those with lower expression, suggesting that suppression of gp140proto-trk strongly correlates with the malignant conversion of the tumor. However, we found that neither autophosphorylation of gp140proto-trk nor tyrosine phosphorylation of cellular proteins was elevated in tumors of the higher expression group. These results suggest that gp140proto-trk does not actively participate in the process of transformation or the suppression of malignant conversion. Rather, the higher level of gp140proto-trk may reflect the greater level of differentiation of tumor cells." @default.
• W2064430449 created "2016-06-24" @default.
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• W2064430449 date "1994-01-01" @default.
• W2064430449 modified "2023-09-25" @default.
• W2064430449 title "Abundant but Inactive-state gpl40prototrkIs Expressed in Neuroblastomas of Patients with Good Prognosis" @default.
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• W2064430449 doi "https://doi.org/10.1111/j.1349-7006.1994.tb02883.x" @default.
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