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• W2064433193 abstract "B-1 B cells have been proposed to be preferentially generated from fetal progenitors, but this view is challenged by studies concluding that B-1 production is sustained throughout adult life. To address this controversy, we compared the efficiency with which hematopoietic stem cells (HSCs) and common lymphoid progenitors (CLPs) from neonates and adults generated B-1 cells in vivo and developed a clonal in vitro assay to quantify B-1 progenitor production from CLPs. Adult HSCs and CLPs generated fewer B-1 cells in vivo compared with their neonatal counterparts, a finding corroborated by the clonal studies that showed that the CLP compartment includes B-1– and B-2–specified subpopulations and that the former cells decrease in number after birth. Together, these data indicate that B-1 lymphopoiesis is not sustained at constant levels throughout life and define a heretofore unappreciated developmental heterogeneity within the CLP compartment." @default.
• W2064433193 created "2016-06-24" @default.
• W2064433193 creator A5014146448 @default.
• W2064433193 creator A5084960183 @default.
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• W2064433193 date "2011-08-01" @default.
• W2064433193 modified "2023-10-17" @default.
• W2064433193 title "Reduced production of B-1–specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells" @default.
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• W2064433193 doi "https://doi.org/10.1073/pnas.1107172108" @default.
• W2064433193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3158209" @default.
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