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• W2064451566 abstract "Activation of hepatic stellate cells (HSC) to a myofibroblast-like phenotype is the pivotal event in liver fibrosis. In uninjured liver, HSC are quiescent and non-dividing, but upon liver injury these cells undergo a dramatic change in phenotype which generates activated myofibroblast-like HSC. The change in phenotype is underpinned by a global change in gene expression with hundreds of genes being up- or downregulated. Molecular events that orchestrate changes in gene expression take place at the level of chromatin packaging which is altered through three main processes: histone modifications, DNA methylation, and silencing by non-coding RNAs. The present review focuses on the epigenetic regulation of HSC activation." @default.
• W2064451566 created "2016-06-24" @default.
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• W2064451566 date "2008-03-01" @default.
• W2064451566 modified "2023-10-17" @default.
• W2064451566 title "Epigenetic regulation of hepatic stellate cell activation" @default.
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• W2064451566 doi "https://doi.org/10.1111/j.1440-1746.2007.05295.x" @default.
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