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- W2064452207 abstract "Here, we report the covalently conjugation of lanthanide doped NaGdF4:Yb3+, Er3+@NaGdF4 upconverting nanoparticles (UCNPs) on methylphosphonate functionalized silica nanospheres (pSi NPs) for in vivo upconversion luminescence (UCL), T1-weighted magnetic resonance (MR), and X-ray computed tomography (CT) multi-modality imaging. The nanocomposites ([email protected]) were synthesized by a facile ligand exchange strategy. The hydrophobic [email protected] were transferred into aqueous solution by surface coating Pluronic F127. The Pluronic F127 coated [email protected] ([email protected]@F127) exhibit excellent stability in biological medium, inappreciable cytotoxicity and negligible organ toxicity. The [email protected]@F127 also shows brighter UCL, and higher CT/MR enhancements than that of Pluronic F127 coated NaGdF4:Yb3+, Er3+@NaGdF4 UCNP. In detail, the capability of [email protected]@F127 as high performance contrast agents for in vivo multi-modality (UCL/MR/CT) imaging is evaluated successfully through small-animal experiments." @default.
- W2064452207 created "2016-06-24" @default.
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- W2064452207 date "2013-07-01" @default.
- W2064452207 modified "2023-10-16" @default.
- W2064452207 title "Conjugation of NaGdF4 upconverting nanoparticles on silica nanospheres as contrast agents for multi-modality imaging" @default.
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- W2064452207 doi "https://doi.org/10.1016/j.biomaterials.2013.03.058" @default.
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