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- W2064471982 abstract "This report shows that, in 8- to 10-month-old BALB/c mice immunized intraperitoneally with dextran B1355, approximately 75% of IgG3 anti-α(l→3) polyglucan (anti-dex) plaque-forming cells (PFC) detected in the spleen were identified as double-Ig class producers secreting simultaneously IgG3 and IgM antibodies with the same specificity for the dex epitope. Under the same conditions of immunization, however, IgA anti-dex PFC were mostly single-class secretors. IgA PFC developed in the spleen in highest numbers (equal to IgM), but in Peyer's patches IgA FFC were sevenfold more numerous than IgM. Furthermore, spleen IgG3 anti-dex PFC responses were low compared with spleen IgA and IgM anti-dex PFC responses and appeared only late in ontogeny. The possibility is discussed whether a TH dependence of the IgA anti-dex response and a TH-independent generation of the IgG3 response are responsible for the different pattern of isotype expression." @default.
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- W2064471982 date "1985-02-01" @default.
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- W2064471982 title "In Vivo Isotype Regulation of Humoral Responses to Dextran B1355 in BALB/c Mice Double-Class IgG3/IgM Producers as a Function of Age" @default.
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- W2064471982 doi "https://doi.org/10.1111/j.1365-3083.1985.tb01417.x" @default.
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