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- W2064492610 abstract "Paraquat dichloride was administered (45 mg/kg i.p.) to male Sprague-Dawley rats. The rats were sacrificed at different times after treatment. Blood was collected and plasma was used for various biochemical measurements. A significant increase in creatine phosphokinase activity was obtained at 12, 24, and 48 hr after paraquat treatment. The activities of glutamic oxaloacetic transaminase (GOT) and sorbitol dehydrogenase were also consistently elevated in paraquat-treated animals but a statistically significant increase was obtained only at 48 hr for GOT. Paraquat had no effect on glutamic pyruvic transaminase activity. Paraquat caused a marked increase in blood glucose and a marked depletion of liver glycogen that lasted for at least a period of 48 hr. The plasma insulin level in paraquat-treated animals was markedly depressed as compared to saline control. Various possibilities have been discussed for the hyperglycemic and liver glycogen-depleting effects of paraquat in the rat." @default.
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- W2064492610 date "1979-12-01" @default.
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- W2064492610 title "Effect of paraquat on plasma enzymes, insulin, glucose, and liver glycogen in the rat" @default.
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- W2064492610 doi "https://doi.org/10.1016/0013-9351(79)90005-7" @default.
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