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- W2064494365 abstract "Abstract The purpose of the present study was to examine the effects of carotid artery constriction on cerebrovascular ultrastructure and permeability in severe two-kidney Goldblatt hypertension in the rat, a renin-angiotensin dependent state. The right common carotid artery of male Holtzman rats was constricted with a silver wire clip having an i.d. of 0.27 mm. Forty-eight hours later the left renal artery of these animals was similarly constricted. Severely hypertensive animals (b.p. > 200 mmHg) and controls were injected with horseradish peroxidase (HRP) and sacrificed 5–20 min later. Parietal cortex supplied by unconstricted and constricted carotid arteries was then processed for light and electron microscopy and cytochemistry. The cerebral cortical arterial vessels from the contralateral hemisphere of the hypertensive animals are tortuous and exhibit segmental constrictions. Ultrastructural examination reveals arterial hyalinosis and intramural and perivascular fibrin deposition. HRP penetrates interendothelial arterial junctions and is found within the subendothelial space, around medial smooth muscle cells and between swollen cell processes of the neuropile. The penetrating arterial vessels of the ipsilateral hemisphere also exhibit increased permeability to HRP but there are no morphologic alterations in the arterial vasculature or adjacent neuropile. Since carotid artery constriction effectively excludes elevated arterial pressure (intracarotid pressure ≤ 145 mmHg) as the cause of the abnormal cerebrovascular permeability, it is suggested that the increased permeability in this system is due to angiotensin-mediated contraction of cerebral arterial endothelium." @default.
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- W2064494365 title "Cerebrovascular ultrastructure and permeability after carotid artery constriction in experimental hypertension" @default.
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- W2064494365 doi "https://doi.org/10.1016/0014-4800(78)90005-9" @default.
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