Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064496460> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2064496460 endingPage "2190" @default.
- W2064496460 startingPage "2187" @default.
- W2064496460 abstract "Mice lacking the μ-opioid receptor gene have been developed by a gene knockout procedure. In this study, the activity of opioid receptor coupled G-proteins was examined to investigate whether there is a change in the extent of coupling for μ-, δ-, and κ-opioid receptors in μ-opioid receptor knockout mice. Selective agonists of μ- (DAMGO), δ- (DPDPE), and κ- (U-69,593) opioid receptors stimulated [35S]GTPγS binding in the caudate putamen and cortex of wild-type mice. In contrast, only U-69,593 stimulated [35S]GTPγS binding in these regions of μ-opioid receptor knockout mice. These results confirmed the absence of G-protein activation by a μ-opioid receptor agonist in μ-opioid receptor knockout mice, and demonstrated that coupling of the κ-opioid receptor to G-proteins is preserved in these mice. However, G-protein activation by the δ-opioid receptor agonist, DPDPE, was reduced in the μ-opioid receptor knockout mice, at least in the brain regions studied using autoradiography." @default.
- W2064496460 created "2016-06-24" @default.
- W2064496460 creator A5043112437 @default.
- W2064496460 creator A5055747865 @default.
- W2064496460 creator A5068898494 @default.
- W2064496460 date "1981-08-01" @default.
- W2064496460 modified "2023-09-27" @default.
- W2064496460 title "Alterations of regional γ-aminobutyric acid receptors in morphine tolerant mice" @default.
- W2064496460 cites W1684853394 @default.
- W2064496460 cites W1775749144 @default.
- W2064496460 cites W1965089972 @default.
- W2064496460 cites W1968346353 @default.
- W2064496460 cites W2003013600 @default.
- W2064496460 cites W2004075868 @default.
- W2064496460 cites W2030852237 @default.
- W2064496460 cites W2043414581 @default.
- W2064496460 cites W2047700693 @default.
- W2064496460 cites W2049503235 @default.
- W2064496460 cites W2066628109 @default.
- W2064496460 cites W2081793131 @default.
- W2064496460 cites W2090447712 @default.
- W2064496460 cites W2091689165 @default.
- W2064496460 cites W2102420653 @default.
- W2064496460 cites W2293483259 @default.
- W2064496460 doi "https://doi.org/10.1016/0006-2952(81)90245-8" @default.
- W2064496460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6271136" @default.
- W2064496460 hasPublicationYear "1981" @default.
- W2064496460 type Work @default.
- W2064496460 sameAs 2064496460 @default.
- W2064496460 citedByCount "20" @default.
- W2064496460 crossrefType "journal-article" @default.
- W2064496460 hasAuthorship W2064496460A5043112437 @default.
- W2064496460 hasAuthorship W2064496460A5055747865 @default.
- W2064496460 hasAuthorship W2064496460A5068898494 @default.
- W2064496460 hasConcept C104317684 @default.
- W2064496460 hasConcept C126322002 @default.
- W2064496460 hasConcept C134018914 @default.
- W2064496460 hasConcept C14397066 @default.
- W2064496460 hasConcept C170493617 @default.
- W2064496460 hasConcept C182704531 @default.
- W2064496460 hasConcept C185592680 @default.
- W2064496460 hasConcept C2776401185 @default.
- W2064496460 hasConcept C2777803847 @default.
- W2064496460 hasConcept C2778938600 @default.
- W2064496460 hasConcept C2779886867 @default.
- W2064496460 hasConcept C2781063702 @default.
- W2064496460 hasConcept C55493867 @default.
- W2064496460 hasConcept C71924100 @default.
- W2064496460 hasConcept C75184817 @default.
- W2064496460 hasConcept C77957584 @default.
- W2064496460 hasConcept C86803240 @default.
- W2064496460 hasConcept C88016717 @default.
- W2064496460 hasConcept C98274493 @default.
- W2064496460 hasConceptScore W2064496460C104317684 @default.
- W2064496460 hasConceptScore W2064496460C126322002 @default.
- W2064496460 hasConceptScore W2064496460C134018914 @default.
- W2064496460 hasConceptScore W2064496460C14397066 @default.
- W2064496460 hasConceptScore W2064496460C170493617 @default.
- W2064496460 hasConceptScore W2064496460C182704531 @default.
- W2064496460 hasConceptScore W2064496460C185592680 @default.
- W2064496460 hasConceptScore W2064496460C2776401185 @default.
- W2064496460 hasConceptScore W2064496460C2777803847 @default.
- W2064496460 hasConceptScore W2064496460C2778938600 @default.
- W2064496460 hasConceptScore W2064496460C2779886867 @default.
- W2064496460 hasConceptScore W2064496460C2781063702 @default.
- W2064496460 hasConceptScore W2064496460C55493867 @default.
- W2064496460 hasConceptScore W2064496460C71924100 @default.
- W2064496460 hasConceptScore W2064496460C75184817 @default.
- W2064496460 hasConceptScore W2064496460C77957584 @default.
- W2064496460 hasConceptScore W2064496460C86803240 @default.
- W2064496460 hasConceptScore W2064496460C88016717 @default.
- W2064496460 hasConceptScore W2064496460C98274493 @default.
- W2064496460 hasIssue "15" @default.
- W2064496460 hasLocation W20644964601 @default.
- W2064496460 hasLocation W20644964602 @default.
- W2064496460 hasOpenAccess W2064496460 @default.
- W2064496460 hasPrimaryLocation W20644964601 @default.
- W2064496460 hasRelatedWork W1966153991 @default.
- W2064496460 hasRelatedWork W1976394800 @default.
- W2064496460 hasRelatedWork W1982495583 @default.
- W2064496460 hasRelatedWork W2002381450 @default.
- W2064496460 hasRelatedWork W2032408015 @default.
- W2064496460 hasRelatedWork W2046839501 @default.
- W2064496460 hasRelatedWork W2074264681 @default.
- W2064496460 hasRelatedWork W2087731725 @default.
- W2064496460 hasRelatedWork W2091330110 @default.
- W2064496460 hasRelatedWork W2747352167 @default.
- W2064496460 hasVolume "30" @default.
- W2064496460 isParatext "false" @default.
- W2064496460 isRetracted "false" @default.
- W2064496460 magId "2064496460" @default.
- W2064496460 workType "article" @default.