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• W2064500527 abstract "CXCR4, the stromal cell-derived factor-1 receptor, plays an important role in the migration of hematopoietic progenitor/stem cells. The surface and cytoplasmic expression of CXCR4 on human hematopoietic CD34(+) cells was investigated. We show that its surface expression is low, whereas a large part of CXCR4 protein is sequestered intracellularly. Using confocal microscopy, we demonstrated that CXCR4 is colocalized with EEA-1, Rab5, Rab4, and Rab11, which are localized in early and recycling endosomes. No significant colocalization of CXCR4 with lysosomal markers CD63 and Lamp-1 was detected. Using antibody feeding experiments, we report a role for CXCR4 constitutive endocytosis in subcellular localization in stably transduced UT7-CXCR4-GFP and CD34(+) cells. Agonist-independent endocytosis of CXCR4 occurs through clathrin-coated vesicles. These data implicate a constitutive endocytosis in the regulation of CXCR4 membrane expression and suggest that constitutive endocytosis may be involved in the regulation of trafficking the human hematopoietic progenitor/stem cells to and in the bone marrow microenvironment." @default.
• W2064500527 created "2016-06-24" @default.
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• W2064500527 date "2004-11-01" @default.
• W2064500527 modified "2023-10-16" @default.
• W2064500527 title "Intracellular Localization and Constitutive Endocytosis of CXCR4 in Human CD34⁺Hematopoietic Progenitor Cells" @default.
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• W2064500527 doi "https://doi.org/10.1634/stemcells.22-6-1015" @default.
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