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• W2064501850 endingPage "18064" @default.
• W2064501850 startingPage "18047" @default.
• W2064501850 abstract "Different modulatory inputs commonly elicit distinct rhythmic motor patterns from a central pattern generator (CPG), but they can instead elicit the same pattern. We are determining the rhythm-generating mechanisms in this latter situation, using the gastric mill (chewing) CPG in the crab (Cancer borealis) stomatogastric ganglion, where stimulating the projection neuron MCN1 (modulatory commissural neuron 1) or bath applying CabPK (C. borealis pyrokinin) peptide elicits the same gastric mill motor pattern, despite configuring different gastric mill circuits. In both cases, the core rhythm generator includes the same reciprocally inhibitory neurons LG (lateral gastric) and Int1 (interneuron 1), but the pyloric (food-filtering) circuit pacemaker neuron AB (anterior burster) is additionally necessary only for CabPK rhythm generation. MCN1 drives this rhythm generator by activating in the LG neuron the modulator-activated inward current (IMI), which waxes and wanes periodically due to phasic feedback inhibition of MCN1 transmitter release. Each buildup of IMI enables the LG neuron to generate a self-terminating burst and thereby alternate with Int1 activity. Here we establish that CabPK drives gastric mill rhythm generation by activating in the LG neuron IMI plus a slowly activating transient, low-threshold inward current (ITrans-LTS) that is voltage, time, and Ca(2+) dependent. Unlike MCN1, CabPK maintains a steady IMI activation, causing a subthreshold depolarization in LG that facilitates a periodic postinhibitory rebound burst caused by the regular buildup and decay of the availability of ITrans-LTS. Thus, different modulatory inputs can use different rhythm-generating mechanisms to drive the same neuronal rhythm. Additionally, the same ionic current (IMI) can play different roles under these different conditions, while different currents (IMI, ITrans-LTS) can play the same role." @default.
• W2064501850 created "2016-06-24" @default.
• W2064501850 creator A5017756416 @default.
• W2064501850 creator A5039605609 @default.
• W2064501850 creator A5069625899 @default.
• W2064501850 date "2013-11-13" @default.
• W2064501850 modified "2023-10-17" @default.
• W2064501850 title "Convergent Rhythm Generation from Divergent Cellular Mechanisms" @default.
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• W2064501850 doi "https://doi.org/10.1523/jneurosci.3217-13.2013" @default.
• W2064501850 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3893358" @default.
• W2064501850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24227716" @default.
• W2064501850 hasPublicationYear "2013" @default.
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