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- W2064501897 abstract "Cell growth and differentiation during developmental processes require the activation of many inducible genes. However, eukaryotic chromatin, which consists of DNA and histones, becomes a natural barrier impeding access to the functional transcription machinery. To break through the chromatin barrier, eukaryotic organisms have evolved the strategy of using poly(ADP-ribose) polymerase 1 (PARP1) to modulate chromatin structure and initiate the steps leading to gene expression control. As a structural protein in chromatin, enzymatically silent PARP1 inhibits transcription by contributing to the condensation of chromatin, which creates a barrier against gene transcription. However, once activated by environmental stimuli and developmental signals, PARP1 can modify itself and other chromatin-associated proteins, thereby loosening chromatin to facilitate gene transcription. Here we discuss the roles of PARP1 in transcriptional control during development." @default.
- W2064501897 created "2016-06-24" @default.
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- W2064501897 date "2010-10-01" @default.
- W2064501897 modified "2023-10-15" @default.
- W2064501897 title "The roles of PARP1 in gene control and cell differentiation" @default.
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- W2064501897 doi "https://doi.org/10.1016/j.gde.2010.06.001" @default.
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