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• W2064508719 abstract "Extract: Embryonic mumps virus infection in the avian host leads to fetal growth retardation. The mechanism of this retardation has not been established. The avian host is unique in that the direct effect of a virus on the embryo may be ascertained in the absence of a placenta. Using radioisotope labeling techniques, DNA, RNA, and protein metabolism was investigated in tissues from infected and control chickens. Metabolism in organ tissue cultivated in vitro and then infected was also studied using the same radioisotope techniques. At hatch, the mean body weight of eight experimental chickens infected with mumps virus early during embryonic incubation was significantly less than that of 19 controls. This lower weight was evident in the brain of the infected chickens. The brain and carcass contained decreased amounts of RNA and protein when compared with uninfected control chickens. The kidney was the only other organ in which the protein content in experimental chickens was less than in controls. There was no difference in the DNA content of organs from in ovo-infected and control chickens or organ tissues cultivated in vitro before infection with mumps virus. Similarly, measurements of cell number at the same time were equal. Viral assay of the chickens infected in ovo revealed highest titers of virus in the heart throughout the last half of incubation. Intermediate titers of virus were recovered from the lung, spleen, and skeletal muscle. Low quantities of virus were recovered from the brain and liver. The bursa contained high titers of virus at midincubation but these titers rapidly declined by hatch. Growth retardation in the mumps virus-infected chicken model is not due to a reduction in cell number but appears to be caused by a diminution in cell size. Speculation: The relation between embryonic mumps virus infection and myocarditis is supported by the findings of high titers of virus throughout the incubation period. It is postulated that altered cardiac function results in a state of hypofusion and a preferential effect is seen in the brain with consequent diminution of cell size rather than cell number." @default.
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• W2064508719 date "1975-01-01" @default.
• W2064508719 modified "2023-09-26" @default.
• W2064508719 title "The Biological and Biochemical Pathogenesis of Mumps Virus-induced Embryonic Growth Retardation" @default.
• W2064508719 doi "https://doi.org/10.1203/00006450-197501000-00006" @default.
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