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- W2064513081 abstract "High-throughput screening (HTS) is a powerful approach to drug discovery, but many lead compounds are found to be unsuitable for use in vivo after initial screening. Screening in small animals like C. elegans can help avoid these problems, but this system has been limited to screens with low-throughput or no specific molecular target. We report the first in vivo 1536-well plate assay for a specific genetic pathway in C. elegans. Our assay measures induction of a gene regulated by SKN-1, a master regulator of detoxification genes. SKN-1 inhibitors will be used to study and potentially reverse multidrug resistance in parasitic nematodes. Screens of two small commercial libraries and the full Molecular Libraries Small Molecule Repository (MLSMR) of ∼364,000 compounds validate our platform for ultra HTS. Our platform overcomes current limitations of many whole-animal screens and can be widely adopted for other inducible genetic pathways in nematodes and humans." @default.
- W2064513081 created "2016-06-24" @default.
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- W2064513081 date "2013-04-29" @default.
- W2064513081 modified "2023-10-16" @default.
- W2064513081 title "An Ultra High-Throughput, Whole-Animal Screen for Small Molecule Modulators of a Specific Genetic Pathway in Caenorhabditis elegans" @default.
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- W2064513081 cites W1494313201 @default.
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- W2064513081 cites W1601895281 @default.
- W2064513081 cites W1944127002 @default.
- W2064513081 cites W1967161878 @default.
- W2064513081 cites W1967914548 @default.
- W2064513081 cites W1969070309 @default.
- W2064513081 cites W1973141016 @default.
- W2064513081 cites W1975946030 @default.
- W2064513081 cites W1982660847 @default.
- W2064513081 cites W1991159765 @default.
- W2064513081 cites W1993079485 @default.
- W2064513081 cites W1996648205 @default.
- W2064513081 cites W1997680903 @default.
- W2064513081 cites W2002759367 @default.
- W2064513081 cites W2005500220 @default.
- W2064513081 cites W2006747148 @default.
- W2064513081 cites W2006983532 @default.
- W2064513081 cites W2012098340 @default.
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- W2064513081 cites W2075604280 @default.
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- W2064513081 cites W2131397861 @default.
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- W2064513081 doi "https://doi.org/10.1371/journal.pone.0062166" @default.
- W2064513081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3639262" @default.
- W2064513081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23637990" @default.
- W2064513081 hasPublicationYear "2013" @default.
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