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- W2064520723 abstract "Topotecan and docetaxel are active agents in the treatment of various malignant diseases. Both drugs cause dose-limiting hematologic toxicity. This study defines the maximum tolerated dose (MTD) and dose-limiting toxicity of weekly topotecan when administered in combination with docetaxel 25 mg/m(2) given day 1, 8,15 every 28 days.Thirteen patients were enrolled. Median age was 62 years. Majority of the patients had lung cancer.The maximum tolerated dose was docetaxel 25 mg/m(2) and topotecan 3 mg/m(2) administered weekly. Dose-limiting toxicity was febrile neutropenia. Eight patients developed at least grade 3 neutropenia in all cycles. Non-hematologic toxicities were mild. No objective responses were noted. Two patients with non-small cell lung cancer had stable disease as a best response.Combination docetaxel and topotecan given weekly is tolerable. The recommended phase II dose is docetaxel 25 mg/m(2) and topotecan 3 mg/m(2) day 1, 8, 15 every 28 days." @default.
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- W2064520723 date "2008-01-01" @default.
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- W2064520723 title "A Phase I trial of weekly docetaxel and topotecan for solid tumors" @default.
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- W2064520723 doi "https://doi.org/10.1080/02841860701560340" @default.
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